Project Grant R01DC022650
- Federal Grant Award Summary Harvard Medical School received a $688,796 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), effective August 6, 2025, with a completion date of July 31, 2030. The research project, titled "Serial Transformations in the Olfactory System," investigates how the olfactory system transforms odor chemistry into perception...
- Federal Project Grant Award Summary The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a Project Grant of $205,943 to The Trustees of Columbia University in the City of New York (Health Sciences Division) on June 8, 2025, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award supports basic neuroscience research designed to elucidate the molecular mechanisms underlying olfactory sensory neuron development and...
- Federal Grant Award Summary The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded The Morgridge Institute for Research, Inc. a Project Grant of $495,000 under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) effective August 1, 2025, through July 31, 2027. This award supports fundamental research investigating the mechanisms of mitral cell regeneration in adult zebrafish olfactory bulbs. The research employs a precision genetic...
- Federal Project Grant Award Summary The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded $619,942 to The Trustees of Columbia University in the City of New York, Health Sciences Division, for a five-year Project Grant spanning September 1, 2025 through August 31, 2030. Under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), this award funds basic science research investigating the mechanisms of olfactory receptor gene choice in...
- Federal Grant Award Summary The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $582,552 Project Grant to The Johns Hopkins University on August 1, 2025, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to support a three-year research initiative through July 31, 2028. The project investigates auditory circuit organization and development following gene therapy for congenital deafness caused by otoferlin variants. The...
- Federal Grant Award Summary The Monell Chemical Senses Center received a $532,348 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 20, 2025, with completion targeted for May 31, 2030. The award funds the Monell Scientist Entrepreneurial Program for Healthy Aging (MSEP-HA), an educational initiative that develops standardized smell tests as biomarkers for neurodegenerative diseases such as Alzheimer's disease. The program...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded University of Maryland, Baltimore a $649,766 Project Grant effective March 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This research grant funds a comprehensive five-year investigation examining how hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels mediate olfactory dysfunction in aging and Alzheimer's disease. The project delivers scientific research...
- Federal Project Grant Award Summary The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded The Johns Hopkins University a Project Grant totaling $426,938 on August 1, 2025, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). This two-year research initiative, concluding July 31, 2027, supports structural biology research investigating how insect olfactory ionotropic receptors (IRs) function as chemosensory receptors. The project...
- Federal Project Grant Award Summary Brandeis University received a $1,393,858 Project Grant from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), awarded April 15, 2025, with completion targeted for March 31, 2030. This basic science investigation will provide detailed structural and functional understanding of gustatory receptors (GRs), specifically the GR43A family of sugar...
- Federal Project Grant Award Summary The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $638,908 Project Grant to Stony Brook University on February 2, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). This grant funds a five-year research project extending through January 31, 2031, investigating discrimination learning and neural dynamics in gustatory cortical circuits. The research will deliver scientific...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded Tufts University School of Medicine a Project Grant totaling $779,636 on February 4, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award supports research through January 31, 2031, to characterize and develop therapeutic treatments for an accelerated aging model of the olfactory epithelium—the tissue responsible for smell sensation. The primary deliverables include extensive characterization of a newly engineered nitroreductase enzyme model (OMP-NTR2.0) that mimics age-related olfactory decline within 12 weeks, comparative analysis against human biopsy and donor tissue samples, investigation of respiratory metaplasia mechanisms in aged olfactory tissue, and development and testing of targeted therapeutic interventions based on olfactory epithelial stem cell dynamics. This research addresses a significant public health gap by establishing the first viable preclinical platform for testing therapeutic approaches to olfactory dysfunction, a condition affecting nearly half of individuals by age 80 and correlating with reduced quality of life, mental health disorders, and malnutrition. The project will produce foundational scientific knowledge and experimental methodologies that can accelerate future therapeutic development for smell disorders, representing a critical advancement over previously slow and poorly effective preclinical models in this research domain.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $779.6k | 2/4/26 |