Project Grant R01DC022510

Award Date 12/15/24
Completion Date 11/30/29
Dollars Obligated $634K
Federal Grant Program
93.173
Assistance Type
Project Grant
Place of Performance
Raleigh, NC 27606, USA
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This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders federal grant program (CFDA 93.173), will support research on the use of muscle progenitor (stem) cells to treat vocal fold paralysis. The $631,703 award, effective March 1, 2025 through February 28, 2030, will enable The Washington University in St. Louis to: Repeat preliminary experiments and investigate optimal treatment...
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This Project Grant award, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), aims to develop a non-invasive treatment strategy for vocal fold scarring and laryngeal injuries. The $633,694 grant awarded to North Carolina State University will support research focused on three key objectives:

  1. Conducting an in-depth investigation into the anti-fibrotic and anti-microbial properties of a specially derived vocal fold lamina propria extract (VFLPX) through advanced proteomic analysis and targeted assays.

  2. Assessing the efficacy of VFLPX in promoting wound healing within a rabbit model of vocal fold injury, evaluating its use as a standalone treatment and in conjunction with aerosolized forms.

  3. Rigorously evaluating the safety of nebulized VFLPX in a rat model to ensure its suitability for long-term use in human patients.

The University of Puerto Rico will serve as a sub-awardee, contributing expertise in deriving and characterizing the VFLPX material, as well as assessing its antimicrobial effects and cytocompatibility through in vitro models. The project aims to establish a foundation for developing a less invasive, patient-friendly approach to treating vocal fold and laryngeal injuries.

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