This federal Project Grant award of $104,512, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA program 93.173 "Research Related to Deafness and Communication Disorders", aims to develop novel treatments for vocal fold scarring. The research project, conducted by the University of Wisconsin-Madison, will use CRISPR/Cas-9 gene editing technology to target specific signaling pathways in vocal fold fibroblasts with the goal of preventing their differentiation into scar-forming myofibroblasts. The proposed in vitro studies will assess the effects of gene editing on fibroblast proliferation, differentiation, and extracellular matrix production, with the objective of identifying new therapeutic targets to mitigate vocal fold scarring and improve voice quality for affected patients. The award period runs from September 30, 2025 to August 21, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 5/23/25 | ||
| Not listed | $564 | 5/23/25 | ||
| Not listed | $52.0k | 3/19/25 | ||
| Not listed | $52.0k | 3/19/25 |