This Project Grant award of $767,494 from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) supports the development of human induced pluripotent stem cell-derived inner ear organoid platforms for modeling and treating genetic hearing and balance disorders. The key objectives are to: 1) Establish and optimize 3D inner ear organoid systems from patient-derived stem cells, and 2) Test CRISPR/Cas9-based gene...
This $589,393 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research to elucidate how the neural circuit of the mammalian cochlea assembles during development. The primary objectives are to investigate the roles of inner and outer hair cells, and their innervation by afferent and efferent neurons, in the formation and maturation of the...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) provides $670,318 to the Trustees of Indiana University (Indianapolis) to conduct research on modeling CHARGE syndrome with human inner ear organoids. The key objectives of the 5-year project are to: Establish human embryonic stem cell lines with specific mutations in the CHD7 gene to study its chromatin...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $251,856 to investigate neuroplasticity and early cochlear implant use in humans and rodents. The award supports research aimed at understanding how the brain adapts to the use of cochlear implants, a type of auditory neuroprosthetic that restores hearing and speech perception to...
This $713,170 federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), aims to develop a novel multimodal micro-optical coherence tomography (MM-MOCT) imaging technology. The goal is to obtain high-resolution, cross-sectional images of the cellular microstructure and metabolic activity of the sensorineural cells in the human inner ear. This capability...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will provide $128,922 to The Leland Stanford Junior University to develop a CRISPR-based toolkit for investigating the role of transcription factors in the development of hair cells within inner ear organoids. The research aims to: 1) define the transcription factors involved in in vitro...
This $521,432 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders federal grant program (CFDA 93.173), supports the development of a new computational model of the human auditory subcortex. The model will integrate aspects of binaural processing and efferent gain control to investigate how these factors influence the perception of complex sounds, including speech intelligibility,...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) provides $429,000 to establish human taste organoid models. The University of Colorado-Denver will develop lingual organoid lines from circumvallate papillae (CVP) biopsies obtained postmortem from organ donors. This will involve validating and characterizing the CVP samples, optimizing protocols to...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $1,804,160.00 in funding to the Massachusetts Eye and Ear Infirmary (MEEI) to conduct research on the development and plasticity of neural circuits underlying sound encoding. The key focus of this 5-year grant project is to characterize the regulatory mechanisms governing the...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $417,741 to the Massachusetts Institute of Technology (MIT) from June 2024 through May 2029. The grant supports the development of computational models to replicate human abilities for sound recognition and localization, with the goal of improving prosthetic devices and therapeutic...