Project Grant R01DA064690
- The National Institute on Drug Abuse awarded Thomas Jefferson University $723,388 on May 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate mechanisms regulating central nervous system viral load and reservoir in the context of HIV infection and cocaine use comorbidity. The funded research addresses how DNA-dependent protein kinase mediates transcription-coupled repair during HIV transcription in microglia, the major HIV reservoir in the central nervous...
- The National Institute of Mental Health awarded the University of Southern California $110,228 on November 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate longitudinal effects of ADHD medication usage on neurodevelopment in adolescents. The project analyzes three waves of data (ages 9–10, 11–12, and 13–14 years) from the Adolescent Brain and Cognitive Development (ABCD) study cohort of 11,800 participants to identify cortical, subcortical, and white matter...
- The National Institute on Drug Abuse awarded Drexel University $832,132 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate novel circuit mechanisms underlying opioid-induced dopamine elevations in the nucleus accumbens, operating beyond the canonical midbrain dopamine neuron pathway. The research explores how oxycodone enhances dopamine signals through local circuits in the nucleus accumbens, specifically examining the role of GABA and cholinergic...
- The National Institute on Drug Abuse awarded Arizona State University $314,000 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct secondary data analysis applying mediation mixture modeling and machine learning to identify heterogeneous risk pathways leading to youth substance use initiation. The project uses the Adolescent Brain Cognitive Development (ABCD) Study, a national longitudinal dataset tracking youths' behavioral health, to examine...
- The National Institute on Drug Abuse awarded the University of Pennsylvania $690,437 on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of histone methyltransferase SETD2 in substance use disorders. The recipient will conduct research establishing that SETD2 inhibition attenuates cocaine self-administration through cell-type-specific regulation of alternative splicing and gene expression. The project applies locus-specific epigenetic...
- The National Institute on Drug Abuse awarded Thomas Jefferson University $693,000 on February 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research on xylazine exposure among pregnant women who use opioids and to generate evidence-based approaches to treatment for this population. The research addresses the rapid spread of xylazine across the United States, with xylazine-positive overdoses increasing over 1,000 percent in the South and 750 percent in...
- The National Institute on Drug Abuse awarded Northwestern University $722,218 on March 1, 2026, for research on the effects of developmental environment on dopamine circuit structure and function under the Drug Use and Addiction Research Programs (CFDA 93.279). The project runs through December 31, 2030, with place of performance in Chicago, Illinois. The research investigates how early life stress produces long-lasting impacts on dopamine circuit function and development into adulthood, using...
- The National Institute on Drug Abuse awarded the University of California, San Diego $226,884 on January 30, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct secondary data analysis investigating developmental brain connectomes and nicotine use in adolescence. The research leverages the Adolescent Brain Cognitive Development (ABCD) Study, a longitudinal NIH-funded cohort following over 11,800 youth across ten years, to examine how nicotine and tobacco product...
- The National Institute on Drug Abuse, a component of the Department of Health and Human Services, awarded Drexel University $684,123 on March 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of inflammasomes in the neurobehavioral and transcriptomic effects of cocaine exposure and HIV infection. The research addresses cocaine use disorder in people living with HIV, a population experiencing exacerbated risk for behavioral and cognitive deficits...
- The National Institute on Drug Abuse awarded Virginia Commonwealth University $177,216 on January 11, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research on muscarinic receptor modulation as a pharmacological approach to stimulant use disorder. The project, titled "Muscarinic Receptor Mediation of Cocaine-Dependent Reward Signals: Impact of Pharmacological Modulation," investigates how M1 and M4 muscarinic acetylcholine receptor subtypes...
The National Institute on Drug Abuse awarded Thomas Jefferson University $279,294 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to examine how ADHD stimulant treatment patterns affect substance use outcomes in adolescents. The research leverages longitudinal data from the Adolescent Brain Cognitive Development (ABCD) Study to investigate the causal relationship between different stimulant treatment trajectories—continuous, intermittent, and discontinued—and high-risk substance use behaviors linked to substance use disorder risk. The study will analyze how stimulant timing, duration, and continuation patterns influence risk, accounting for demographic and contextual factors including comorbid psychiatric diagnoses that influence ADHD treatment utilization and long-term outcomes. Thomas Jefferson University, operating as Sidney Kimmel Medical College, is the recipient. Work is performed in Philadelphia, Pennsylvania. The project period runs through May 31, 2030. This is a Project Grant, the assistance type typical for NIH investigator-initiated research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $279.3k | 8/21/26 |