Project Grant R01DA064394
- This Project Grant award of $144,950.00 from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) aims to evaluate the expression, function, and immunomodulatory potential of endocannabinoid receptors, including TRPV2 and PPAR-A, as well as cannabidiol (CBD), in microglia in the context of HIV. The research goal is to investigate how the endocannabinoid system can modulate the HIV-induced inflammatory response in microglia, which is a key driver of...
- This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), totaling $1,742,971 and commencing on April 15, 2025, aims to investigate the role of cannabinoids in modulating cocaine-induced inflammasome activation and epigenetic regulation in the intestine and brain during HIV/SIV infection. The primary objectives are to: 1) examine the impact of cocaine and HIV/SIV on inflammasome activation and its...
- The federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $439,180 to The Johns Hopkins University to investigate the role of dopaminergic neuron-glial interactions in the striatum in the context of HIV infection and substance use disorders. The research aims to deconvolute the complex interplay between HIV, methamphetamine use, and alterations in dopamine signaling pathways, which can contribute...
- This federal Project Grant award, valued at $563,742.00, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research to investigate the impact of HIV infection and cocaine use on lipid metabolism in microglia, a type of brain cell, and the role this plays in the development of neurological symptoms associated with HIV (referred to as NeuroHIV). Key research activities include: Examining how HIV proteins...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $558,668 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Massachusetts Institute of Technology (MIT) for the project "Integration and Validation of Single-Cell Neuronal and Immune Molecular Responses in SUD and HIV". The project aims to uncover the genetic and molecular mechanisms driving the interactions between HIV, neuropsychiatric, and...
- This $616,372 federal Project Grant was awarded on July 15, 2025 by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research to identify neuronal, glial, and neural stem/progenitor cell transposable element (TE) transcriptional and epigenetic gene regulatory states involved in SIV, antiretroviral therapy, and cannabinoid exposure in a non-human primate model. Additionally, the research aims to identify TE expression...
- The National Institute on Drug Abuse (NIDA), under CFDA Program 93.279 - Drug Use and Addiction Research Programs, awarded a $1 project grant to the J. David Gladstone Institutes. The grant aims to establish a novel mouse model for studying the impact of HIV and addictive substances on the central nervous system. Specifically, the project will develop a chimeric mouse model with human microglia, neurons, and astrocytes derived from induced pluripotent stem cells. This model will be used to...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $608,652 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Scripps Research Institute. The purpose of this 5-year award, with a start date of September 1, 2025, is to conduct data mining and functional validation of the Systematic Characterization of Retroviral Conditions for Health (SCORCH) datasets. The research aims to elucidate the key pathogenic...
- This federal Project Grant award, titled "MOLECULAR INTERPLAY OF HIV TAT, COCAINE, AND CART IN MICROGLIAL PYROPTOSIS: ROLE OF NLRP3 INFLAMMASOME", is funded by the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) for $1,372,480. The grant was awarded on April 15, 2025 to the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center (UNMC) division, with an ultimate completion date of January 31, 2030....
- This federal Project Grant award of $240,108 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to elucidate the corticostriatal and neuroimmune mechanisms underlying HIV-induced dysregulation of reward seeking. The award to Drexel University will support research to identify novel treatment targets for individuals with co-occurring cocaine use disorders and HIV. The project will leverage animal models to investigate how HIV...
This Project Grant award of $416,351 from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) supports research by the University of North Carolina at Chapel Hill to explore the use of cannabinoid type 1 receptor (CB1R) positive allosteric modulators as a potential treatment for HIV-associated neurocognitive disorders (HAND). The research aims to investigate the circuitry- and cell-specific effects of CB1R positive allosteric modulators in the context of neuroHIV, with a focus on their neuroprotective, anti-inflammatory, and neurotrophic properties. The project period runs from September 1, 2025 to May 31, 2030, and the research outcomes may provide insights into alternative therapeutic approaches for addressing the persistent neurological complications associated with HIV infection.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $416.4k | 8/13/25 |