Project Grant R01DA064336
- Federal Project Grant Award Summary The University of Pennsylvania received a $247,702 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective July 31, 2025 through January 31, 2028. The grant funds basic neuroscience research investigating the role of mu-opioid receptors in the paraventricular nucleus of the thalamus (PVT) in stress-related behavioral phenotypes and opioid addiction vulnerability. The...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $872,100 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 30, 2025 through May 31, 2030. The grant funds research titled "Dissecting and Modulating Cell Type and Circuit-Specific Epigenetic Mechanisms of Cocaine Addiction," which addresses the substantial public health burden of...
- Federal Grant Award Summary The University of Pennsylvania received a $454,251 Project Grant awarded July 15, 2025, by the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop innovative diagnostic and monitoring tools for opioid use disorder research. The project, extending through June 30, 2027, focuses on creating a device-free blood-based biomarker detection system called Released Markers of Activity (RMAs) to enable long-term...
- Federal Grant Award Summary The University of Pennsylvania received a $1.56 million Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded July 1, 2025, with completion targeted for March 31, 2030. This award supports research investigating the role of central amylin receptors in opioid-mediated behaviors, with the goal of identifying novel neurobiological mechanisms and druggable targets to reduce opioid-taking...
- Federal Project Grant Summary Award Details: Funding Agency: National Institute on Drug Abuse (NIDA) Federal Grant Program: Drug Use and Addiction Research Programs (CFDA 93.279) Principal Awardee: The Pennsylvania State University Total Funding: $1,680,850 Award Date: August 1, 2025 Project Period: August 1, 2025 – May 31, 2030 Research Objectives and Deliverables: This longitudinal research project examines the developmental pathways linking prenatal and postnatal substance exposure (tobacco...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Pennsylvania a $803,570 project grant on August 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a rigorous evaluation of the Hospital-to-Housing (H2H) initiative through May 31, 2030. The project delivers comprehensive research and evaluation services focused on assessing the effectiveness and implementation of H2H, a medically supported transitional housing...
- This $2.11 million Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research conducted by Pennsylvania State University's Milton S. Hershey Medical Center from May 2025 through February 2030. The award funds investigational research on cocaine addiction using an animal model to identify individual vulnerability to addiction early in disease development and to test early intervention strategies. The...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Children's Hospital of Philadelphia Research Institute a $549,436 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) on June 16, 2025, with a completion date of January 31, 2027. This two-year research initiative investigates the neural mechanisms underlying reward-context memories associated with fentanyl use, with the objective of developing novel therapeutic interventions to prevent...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded UC San Diego a $197,500 Project Grant effective September 1, 2025, through August 31, 2027, under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports the development and validation of an innovative in vivo Massively Parallel Reporter Assay (MPRA) platform designed to analyze the functional role of genetic variants and cis-regulatory elements implicated in substance use disorders (SUDs). The...
- Federal Grant Award Summary Drexel University received a $684,123 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded March 15, 2026, with completion scheduled for December 31, 2030. The award funds a cross-model investigation examining the role of inflammasomes in the neurobehavioral and transcriptomic effects of cocaine exposure and human immunodeficiency virus (HIV) infection. The research addresses a...
The University of Pennsylvania received a $690,437 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective May 1, 2026 through February 28, 2031. This research project investigates the role of the histone methyltransferase enzyme SETD2 (SET domain containing 2) in substance use disorders, with particular focus on cocaine addiction. The research will employ locus-specific epigenetic editing techniques using CRISPR/dCas9 to establish direct causal relationships between specific epigenetic modifications and substance use behaviors, advancing understanding of the molecular and epigenetic mechanisms underlying addiction. The deliverables include scientific research establishing both the sufficiency and necessity of SETD2 in driving cocaine-related behaviors through pathway-specific SETD2 overexpression and small-molecule SETD2 inhibition studies. The project will define cell-type specific effects of SETD2 on behavior, histone modifications, and gene expression patterns in brain reward regions, with particular emphasis on the nucleus accumbens. Results are expected to contribute new knowledge regarding epigenetic regulation of alternative splicing and gene expression in substance use disorders, potentially informing future therapeutic interventions targeting SETD2 pathways to attenuate cocaine self-administration and addiction-related behaviors.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $690.4k | 4/21/26 |