Project Grant R01DA063145
- The National Institute of Mental Health (NIMH) awarded a $766,842 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The McLean Hospital Corporation in Belmont, Massachusetts. The grant funding will support a 5-year research project to employ reverse-translated touchscreen assays and electrophysiological recording in rats to identify the neurochemical drivers underlying the prohedonic (pleasure-enhancing) therapeutic efficacy of MDMA. This research aims to advance the...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $508,952 to Yale University to conduct research on the neural mechanisms underlying the effects of MDMA (methylenedioxy-methamphetamine) on the extinction of learned fear responses. The research aims to characterize structural changes in frontal cortex neurons and how they relate to the 5HT2A receptor, which is activated by MDMA. The researchers...
- This $246,000 federal Project Grant awarded on June 15, 2025 by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research at Princeton University to investigate the brain mechanisms underlying the therapeutic potential of psilocybin. The research aims to explore psilocybin's effects on behavioral states, motivated task acquisition, and the associated cellular and brain-wide substrates, from dendritic spines to large-scale...
- The National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $283,968 Project Grant to the Regents of the University of Michigan to build an "AI Forest" to study the social and environmental factors underlying complex behavioral traits in wild white-faced capuchin monkeys in Costa Rica. The project, which runs from March 2025 to February 2027, will leverage new technologies to probe brain-behavior relationships and assess...
- This $249,860 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) will support research to delineate the function and brain circuitry involving a specialized subtype of dual serotonergic-glutamatergic neuron, with the goal of understanding its potential role in linking sleep architecture, substance use disorder, and major affective disorders. The research will be conducted by President and Fellows of Harvard College, doing...
- This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop methods for integrating large-scale electron microscopy (EM) brain imaging data with functional and behavioral recordings. The $1,100,864 project, spanning from September 30, 2024 to September 29, 2027, will focus on relating the structure and function of neural circuits in the Drosophila brain. The proposed research seeks to...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $125,879 to President and Fellows of Harvard College (doing business as Harvard Medical School) to characterize how hunger and hypothalamic neuron activity modulate exploratory behavior and dopaminergic neural activity in mice. The project aims to study how caloric deprivation affects mouse exploratory behavior and dopamine release in the...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $558,668 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Massachusetts Institute of Technology (MIT) for the project "Integration and Validation of Single-Cell Neuronal and Immune Molecular Responses in SUD and HIV". The project aims to uncover the genetic and molecular mechanisms driving the interactions between HIV, neuropsychiatric, and...
- This federal Project Grant award for $330,027.00 from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) supports research to develop a computational-experimental framework for characterizing the complex dynamics of naturalistic social interaction across neural, behavioral, and social scales. The project will utilize simultaneously recorded behavioral and electrophysiology data from ferrets during natural social interactions to construct multiscale...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $613,107.00 to the Massachusetts Institute of Technology (MIT) from January 1, 2025 to November 30, 2029. The project aims to apply a novel brain imaging method called BLUSH to study brain-wide neuroplasticity and its relationship to neural activity, structural changes, and individual behavioral variability. Specific research objectives include:...
This federal Project Grant award of $712,500.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to investigate the impact of MDMA and methamphetamine on the visual and associative regions of the macaque monkey brain. The research project, titled "The Mechanistic Role of Visual Areas at the Interaction of Social Behavior and Drug Effects in Nonhuman Primates", will use electrophysiology and deep neural networks to determine how social viewing affects drug-taking and integration. The project hypothesizes that positive social stimulation reduces drug-taking impulses and that MDMA biases prosocial free viewing. The research will track long-term properties of proto-social and other neurons in multiple visual areas using chronically implanted microelectrode arrays and naturalistic social behavioral tasks under repeated drug administration. This will assess chronic drug effects and inform future therapies. The grant was awarded to President and Fellows of Harvard College, doing business as Harvard Medical School, and is expected to run from Sep 1, 2025 to May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $712.5k | 8/26/25 |