The National Institute of Mental Health (NIMH) has awarded a $766,842 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to The Mclean Hospital Corporation in Belmont, MA. The grant, titled "MDMA Mechanisms of Prohedonic Efficacy: A Reverse Translational Approach", will fund a 5-year research project to study the therapeutic potential of MDMA (commonly known as Ecstasy) for treating post-traumatic stress disorder (PTSD) and depression. The key focus of the...
This $418,750 federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to mechanistically uncover the neuroanatomical substrates of anxiety-related brain circuits in humans. The award supports research conducted by Yale University that will use invasive neurophysiology techniques in epilepsy patients to investigate the distinct roles of the dorsal anterior cingulate cortex and anterior insula in...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA program 93.242 Mental Health Research Grants, will support research into the neurocircuitry underlying motivated reward-seeking behavior as a coping mechanism for stress. The $606,029 award, effective August 1, 2024 through July 31, 2025, will be administered by the University of Massachusetts Medical School. The key objectives are to investigate how sub-populations of neurons in the medial...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants provides $1,932,991 to conduct research on the neural computations underlying learning, decision-making, and memory. The goal is to characterize core computations of value, uncertainty, and prediction error across cognitive processes and domains, and to identify associations between these computations and symptoms of anxiety and stress-related disorders. The research...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,072,702 to the University of Vermont & State Agricultural College to investigate the neural substrates underlying the encoding and retrieval of higher-order fear memories. The research aims to use chemogenetic and electrophysiological recording methods in freely moving rats to study how cortical networks process and represent these types of...
The National Institute on Drug Abuse (NIDA) awarded a $1,499,050 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to the Medical College of Wisconsin, Inc. for the project "Investigations into 5-HT2A Signaling Mechanisms of Psychedelic Drugs for the Treatment of Stimulant Use Disorder". This grant, with a period of performance from May 15, 2024 to March 31, 2029, aims to investigate the role of 5-HT2A receptor signaling in suppressing the reinforcing effects of...
The National Institute of Mental Health (NIMH) awarded a $434,610 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Florida Institute of Technology Inc. (Florida TECH) to develop light-triggered molecular tools critical for understanding the brain's neural network. The 3-year project, awarded on December 16, 2024, aims to create photoswitchable molecular "cages" that can precisely control calcium ion concentrations to enable neuroscientist collaborators,...
Yale University received a $1,351,106 Project Grant award from the Defense Health Agency under the Military Medical Research and Development federal grant program (CFDA 12.420). The three-year award beginning July 1, 2023 will support research to identify circuit mechanisms of MDMA and methylone in order to develop plasticity-based post-traumatic stress disorder (PTSD) treatment. Through this funding, Yale researchers will investigate medical solutions applicable to battlefield conditions by...
The National Institute of Mental Health (NIMH) awarded a $267,310 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Trustees of Boston University's Medical Campus to study inhibitory neurotransmission in the prefrontal cortex of rhesus macaques. The research aims to understand how compartment-specific inhibition and laminar circuit dynamics in the lateral prefrontal cortex (LPFC) and anterior cingulate cortex (ACC) contribute to cognitive and emotional disturbances in...
The University of Chicago was awarded a $617,737 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant will fund a research project investigating the role of the thalamic nucleus reuniens in suppressing and extinguishing contextual fear memories, which is critical for understanding and treating post-traumatic stress disorder (PTSD). Through this project, the researchers will use advanced techniques like 2-photon...