This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $240,108 to Drexel University to elucidate the corticolimbic circuit and neuroimmune mechanisms underlying the dysregulation of reward-seeking behavior in the comorbid condition of HIV and cocaine use disorder (CUD). The research aims to use circuit-specific optogenetics and chemogenetics in mouse models to understand how HIV infection,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,223,769 to the University of California, San Diego (UCSD) to conduct research on the intertwined mechanisms of HIV and opioid use on mitochondrial-mediated inflammasome activation and neurotoxicity. The research aims to elucidate how the convergence of HIV infection and opioid use leads to more severe neurological consequences, including...
This federal Project Grant award for $263,119 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) is focused on developing NLRP3 inhibitors to address HIV-associated neuroinflammation in cocaine use. The key objectives are to computationally design, synthesize, and screen novel analogues of a lead compound, AMS-17, to improve its biological activity and maintain low toxicity. The project involves in vitro and in vivo screening of...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $454,470.00 in funding to Drexel University to develop a new imaging pipeline and analytical approach for examining the spatial architecture of histone dopaminylation in the central nervous system (CNS) of mice with HIV infection that self-administer cocaine. The goal is to connect molecular-level epigenetic changes with behavioral outcomes...
This Project Grant award of $558,668 from the National Institute on Drug Abuse (NIDA) under CFDA Program 93.279 - Drug Use and Addiction Research Programs supports research to elucidate the shared and distinct molecular mechanisms underlying the interplay between HIV, substance use disorders (SUD), and neuropsychiatric/neurodegenerative conditions. The award to Massachusetts Institute of Technology (MIT) aims to leverage single-cell transcriptomic, epigenomic, and spatial datasets along with...
The National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $1,372,480 Project Grant to the Board of Regents of the University of Nebraska's University of Nebraska Medical Center (UNMC). The grant supports a 5-year research study focused on elucidating the molecular mechanisms underlying the interplay between HIV transactivator of transcription (Tat) protein, cocaine, and combination antiretroviral therapy (cART) in activating the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $880,000 to Old Dominion University from September 2024 through August 2026. The project aims to investigate the therapeutic effects of microglia depletion and repopulation (MGDR) on mitigating hand and neuropsychiatric symptoms in the context of chronic HIV infection. Specifically, the research will explore the impact of MGDR on brain pathology in HIV-infected mouse models, examining its...
This Project Grant award of $2,312,085, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the molecular mechanisms linking HIV infection and opioid use disorder that contribute to neuroinflammation and HIV-associated neurocognitive disorders (HAND). The research, led by the Trustees of Boston University's Medical Campus, will utilize primary human iPSC-derived microglia cultures to...
The National Institute on Drug Abuse (NIDA) awarded a $558,085 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to the University of California, Irvine (UCI) to support an interdisciplinary research initiative titled "DMFV-SCORCH Project". This 5-year project aims to uncover multi-scale dysregulations resulting from HIV and opioid use disorder (OUD) through population-scale single-nuclei sequencing data analysis and functional validations using advanced genomic...
This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the NIH's Drug Use and Addiction Research Programs (CFDA 93.279), will fund a $751,043 research project at the University of Massachusetts Medical School focused on investigating the cellular and molecular mechanisms underlying the complex co-morbidity of opioid use disorder (OUD), major depressive disorder (MDD), and HIV in the human brain. The project will leverage single-cell sequencing technologies and other...