Project Grant R01DA062257

Award Date 9/30/24
Completion Date 7/31/29
Dollars Obligated $708K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Stony Brook, NY 11794, USA
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The key objectives of this 5-year research project are to: 1) construct a cell atlas of opioid-targeted inflammasomes in the spinal cord of HIV pain models, 2) elucidate the role of Wnt5a signaling in establishing inflammasome cell maps, and 3) determine the contribution of glial type-specific NLRP3 inflammasomes to OIH pathogenesis in the context of HIV-associated pain. The results are expected to reveal the molecular mechanisms and pathogenic role of opioid-targeted inflammasomes in the central nervous system for HIV-associated pain.

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