The Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center (UNMC) division, was awarded a $1,381,500 Project Grant (Federal Grant ID R01DA061678) from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) to explore the role of sex differences in establishing and maintaining HIV/SIV reservoirs in the context of opioid use.
The overarching goal of this 5-year research project is to utilize a rhesus macaque model of SIV infection to comprehensively document sex-based differences in the size, location, and persistence of viral reservoirs, with a particular focus on how opioid exposure, such as chronic morphine use, may modulate these reservoirs differently in male versus female animals. This research aims to provide insights that could inform the development of more effective HIV cure strategies accounting for sex-based factors.
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