Project Grant R01DA060066
- Federal Grant Award Summary The National Institute on Drug Abuse awarded a Project Grant of $182,697 (effective May 1, 2025, through August 30, 2026) to the University of Texas Health Science Center at San Antonio under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research evaluating cannabidiol (CBD) as an adjuvant therapeutic agent for opioid use disorder (OUD) treatment. The research addresses a critical public health challenge, as approximately half of OUD patients...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The University of Kentucky Research Foundation a $647,142 Project Grant on February 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct controlled research examining the impact of cannabis on opioid self-administration in individuals with opioid use disorder. The research will be completed by November 30, 2030, and will deliver fundamental public health data addressing a critical gap...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Albert Einstein College of Medicine a $199,584 Project Grant, effective March 15, 2026, through February 28, 2031, under the Drug Use and Addiction Research Programs (CFDA 93.279). Dr. Michele Buonora will conduct a five-year hybrid effectiveness-implementation study examining patient-controlled analgesia (PCA) for acute pain management in hospitalized individuals with opioid use disorder (POUD). The research will...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Massachusetts General Hospital $395,280 under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and evaluate AMP-C, a digital therapeutic (DTX) intervention targeting reward dysfunction in individuals with co-occurring Cannabis Use Disorder (CUD) and Major Depressive Disorder (MDD). This five-year project grant, effective July 1, 2025 through June 30, 2030, delivers a user-centered digital...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Regents of the University of Colorado-Denver a Project Grant totaling $2.89 million under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a comprehensive, multidisciplinary investigation of cannabis use's impact on pain and recovery following total knee arthroplasty (TKA) surgery. The research, which commenced September 5, 2025, and extends through August 31, 2030,...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Boston Children's Hospital a $489,500 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning June 1, 2025 and concluding May 31, 2027. This research initiative develops and validates remote oral fluid testing procedures to assess cannabis non-use as a key outcome measure in clinical trials targeting younger adults aged 18-30 years with cannabis use disorder (CUD). The project...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Washington University $1,320,580 under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research on the analgesic potential of novel peripherally-restricted cannabinoid type 1 receptor (CB1R) ligands. The award, effective August 1, 2025, through April 30, 2030, funds preclinical research designed to bridge the gap between promising laboratory findings and inconsistent clinical...
- Federal Cooperative Agreement Summary The National Institute on Drug Abuse (NIDA) awarded a $1.37 million Cooperative Agreement to New York University School of Medicine, effective July 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and test a telehealth-delivered transcranial direct current stimulation (tDCS) intervention for cannabis use disorder (CUD). The C.A.R.E.S. (Cannabis Addiction Recovery Enhancement Stimulation) Initiative combines home-based...
- Syncanica Bio, Inc. received a Project Grant of $334,343 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded June 15, 2025, with completion targeted for May 31, 2027. The company is developing fully synthetic analogs of 8,9-dihydrocannabidiol (H2CBD) as therapeutic agents to treat substance use disorder (SUD), a public health crisis with limited treatment options. This research builds on preliminary evidence indicating that...
- Federal Cooperative Agreement Summary George Washington University received a $2.1 million Cooperative Agreement from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research evaluating oxytocin (OXT), an FDA-approved medication, as a novel therapeutic intervention for opioid-induced respiratory depression (OIRD). The research initiative, awarded July 1, 2025, with completion expected June 30, 2027, addresses the critical...
COMBINATION OF THC AND CBD AS A NOVEL TREATMENT FOR CO-OCCURRING OPIOID ADDICTION AND CHRONIC PAIN - PROJECT SUMMARY/ABSTRACT THIS APPLICATION AIMS TO EXAMINE THE COMBINED ANALGESIC AND ANTI-CRAVING EFFECTS OF DELTA-9- TETRAHYDROCANNABINOL (THC) AND CANNABIDIOL (CBD) IN INDIVIDUALS WITH CO-OCCURRING OPIOID USE DISORDER (OUD) AND CHRONIC PAIN UNDERGOING OPIOID AGONIST THERAPY. CHRONIC PAIN AFFECTS UP TO 60% OF PEOPLE WITH OUD, LEADING TO GREATER MORBIDITY AND MORTALITY. YET, PAIN IS OVERLOOKED IN OUD TREATMENT DUE TO THE LACK OF EFFECTIVE THERAPIES ADDRESSING BOTH CONDITIONS. HENCE, THERE IS AN URGENT NEED FOR NOVEL THERAPEUTIC APPROACHES. THC HAS BEEN SHOWN TO MITIGATE PAIN, WHILE CBD REDUCES CUE-INDUCED OPIOID CRAVING. SOME EVIDENCE ALSO SUGGESTS THAT CBD MAY COUNTERBALANCE THC'S UNDESIRED EFFECTS. HOWEVER, THE COMBINED EFFECTS OF THC AND CBD ON INDIVIDUALS WITH CO-OCCURRING OUD AND CHRONIC PAIN REMAIN UNKNOWN. STUDYING THIS POPULATION IS CRUCIAL, AS THE CO-OCCURRENCE OF PAIN AND OUD CAUSES UNIQUE NEUROADAPTATIONS, CLINICAL TRAJECTORIES, AND POORER OUTCOMES. TO CLOSE THIS CRITICAL KNOWLEDGE GAP, WE PROPOSE A HUMAN LABORATORY STUDY TO CHARACTERIZE THE COMBINED THERAPEUTIC EFFECTS OF THC AND CBD AMONG PEOPLE WITH CO-OCCURRING OUD AND CHRONIC PAIN WHO ARE UNDERGOING OPIOID AGONIST THERAPY. THE STUDY WILL INVESTIGATE THE COMBINED EFFECTS OF THC AND CBD ON TWO IMPORTANT TRIGGERS OF NON-MEDICAL OPIOID USE: PAIN SENSITIVITY AND CUE-INDUCED OPIOID CRAVING, ASSESSED USING MULTIMODAL QUANTITATIVE SENSORY TESTING (QST) AND A WELL-VALIDATED VISUAL PROBE TASK THAT INVOLVES THE PRESENTATION PARTICIPANT-MATCHED OPIOID CUES (I.E., HEROIN PARAPHERNALIA), RESPECTIVELY. THREE GROUPS OF 40 PARTICIPANTS WILL BE RANDOMIZED TO SINGLE DOSES OF ORAL THC (5 MG, 10 MG) AND CBD (400 MG, 800 MG, 1200 MG), ACROSS FOUR TEST SESSIONS SEPARATED BY THREE DAYS EACH. THE STUDY WILL HAVE 3X4 DESIGN, WITH THC DOSE AS A BETWEEN-SUBJECT FACTOR AND CBD DOSE AS A WITHIN-SUBJECT FACTOR. PARTICIPANTS WILL MEET DSM-5 CRITERIA FOR OUD, HAVE CHRONIC NON-CANCER LOW BACK PAIN FOR 3 MONTHS, AND WILL BE RECEIVING STABLE DOSES OF METHADONE (40-120 MG/DAY). THIS STUDY WILL HAVE A SIGNIFICANT IMPACT FOR THIS UNDER-RESEARCHED POPULATION, BY DETERMINING THE COMBINED EFFECTS OF THC/CBD FOR RELIEVING PAIN SENSITIVITY AND CUE-INDUCED OPIOID CRAVING, TWO KEY TREATMENT TARGETS (AIM 1); AND DETERMINING THE ABUSE POTENTIAL AND COGNITIVE/PSYCHOMOTOR EFFECTS OF COMBINED THC/CBD, ADMINISTERED WITH OPIOID AGONIST MAINTENANCE (AIM 2). THIS STUDY WILL ALSO INVESTIGATE IF SEX INFLUENCES THE RESPONSES TO THC/CBD; THE COMBINED EFFECTS OF EFFECTS OF THC/CBD ON CENTRAL SENSITIZATION; AND POTENTIAL DRUG INTERACTIONS, INDEXED BY PLASMA OPIOID, THC, AND CBD LEVELS (EXPLORATORY AIMS). THIS APPLICATION WILL ADVANCE THE UNDERSTANDING OF THC/CBD COMBINATIONS AS NON-OPIOID THERAPEUTICS, SUPPORTING NEW DRUG APPLICATIONS FOR CO-OCCURRING OUD AND CHRONIC PAIN. FINALLY, OUR MODEL FOR ASSESSING BOTH OUD AND PAIN TREATMENT TARGETS WILL ESTABLISH A BENCHMARK TO EVALUATE NOVEL THERAPIES, ADDRESSING NIH'S PRIORITIES AND INFORMING PATIENTS, HEALTHCARE PROFESSIONALS, AND POLICY STAKEHOLDERS AMIDST THE OPIOID CRISIS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $45.5k | 2/6/26 | ||
| Not listed | $409.1k | 1/26/26 | ||
| Not listed | $409.1k | 1/26/26 | ||
| Not listed | $454.5k | 7/10/25 | ||
| Not listed | $454.5k | 7/10/25 |