This $707,947 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to investigate the effects of methamphetamine use on inflammasome activation and immune dysfunction in individuals with HIV infection. The project aims to determine how methamphetamine impacts inflammasome activation and T cell function during HIV infection, with or without antiretroviral therapy (ART). It will also examine the therapeutic potential of targeting autophagy, a cellular process, to reduce excessive inflammasome activation and restore T cell function. Additionally, the project will investigate the effects of methamphetamine and autophagy induction on HIV-associated central nervous system inflammation. This 5-year award, effective June 1, 2024, will be performed by the University of California, Los Angeles (UCLA) through its Office of Research Administration.
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