This R01 project grant, awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to assess the neurobehavioral impacts of medical cannabis use in a sample of 120 patients aged 35-65 treated with medical cannabis products in Minnesota, compared to 60 non-cannabis using controls. The $1,980,270 grant will fund a comprehensive pre-post assessment of cognitive function, neural activity, and substance use disorder (SUD) risk in...
This Project Grant award, valued at $376,078.00 and funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to explore the antecedents and consequences of cannabis use for coping purposes. The study will experimentally test whether cannabis use quantity increases after a stress induction among individuals who use cannabis to cope, as well as examine factors that may moderate this effect, such as social anxiety...
This $233,250 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to examine the relationship between early cannabis use and later opioid use disorder. The key objectives are to: Estimate the association between early cannabis use and proximal (initial subjective responses) and distal (opioid use disorder criteria) aspects of opioid involvement, and whether these associations are modified by...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a 5-year, $2,726,432 research study on the co-use of cannabis and prescription opioids among emerging adults in medical settings. The study will enroll emerging adults ages 18-25 who are prescribed opioids for acute pain management, with the majority having used cannabis in the past month. The research aims to examine how pain experiences,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to examine the potential effectiveness of transcranial direct current stimulation (tDCS) paired with reappraisal training for the treatment of cannabis use disorder (CUD). The $247,875 award, effective from July 1, 2024 to June 30, 2026, will support a double-blind study with 60 participants assigned to receive either real or sham tDCS alongside...
This $286,984 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund a randomized crossover trial to evaluate the ability of regular cannabis consumers to self-titrate their THC dose when vaping cannabis concentrates of different potencies (30%, 60%, and 90% THC). The study, to be conducted by the Centre for Addiction and Mental Health (CAMH) in Toronto, Canada, will also characterize and compare the...
This $443,263 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund a 5-year study to characterize the effects of recreational cannabis use on sleep in women of childbearing age. The study will pair sleep behavior with nocturnal physiological measures of brain activity, stress reactivity, and autonomic nervous system function to delineate the proximal impacts of acute cannabis exposure across different...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is providing $541,080 over 5 years to support a human laboratory study investigating the effects of repeated cannabidiol (CBD) administration on the abuse-related and analgesic properties of smoked cannabis. The study, led by researchers at Columbia University's Health Sciences Division, will enroll 72 healthy adult cannabis smokers and randomize...
This federal Project Grant award of $2,264,782 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a research study examining the effects of cannabis use and discontinuation on sleep, circadian rhythms, and light sensitivity in 60 emerging adults (ages 18-25) who regularly use cannabis. The study, to be conducted at the University of Pittsburgh, will assess participants' homeostatic sleep drive and circadian...
This Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), is aimed at characterizing the proximal relationship between cannabis use/withdrawal and depressive symptoms/suicidal ideation among adolescents. The $2,286,303 grant will support a 10-week, multi-method, randomized study to recruit 200 school-based adolescents aged 12-18 with daily/near-daily cannabis use, current depression, and recent suicidal...
This $2,078,208 federal Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports a 5-year study investigating the roles of tolerance and withdrawal in the likelihood of a pathological pattern of cannabis use (termed "Cannabis Use Disorder - Medicinal Cannabis" or CUD-MC) among medical cannabis patients.
The study aims to: 1) examine how DSM-5 tolerance is associated with THC dose, specific cannabis effects, and CUD-MC; 2) determine how patterns of medical cannabis use are associated with DSM-5 withdrawal and CUD-MC over 2 years; and 3) identify risk factors for CUD-MC and examine cannabis-related health outcomes over 2 years. The project will recruit 400 medical cannabis patients, aged 18 and older, and use innovative methods like ecological momentary assessment (EMA) to generate new insights into the roles of tolerance and withdrawal in the development of a pathological pattern of cannabis use in this population. The results are expected to inform medical cannabis practice guidelines and the development of personalized interventions to minimize cannabis-related harms.