Project Grant R01CA316299
- Federal Grant Award Summary The National Cancer Institute awarded the University of Chicago a Project Grant of $129,285 under the Cancer Research Manpower program (CFDA 93.398) on June 4, 2026, with completion targeted for May 31, 2028. This research initiative focuses on integrated fatty acid profiling to establish linkages between body mass index (BMI) and the efficacy of anti-tumor immunotherapy. The project systematically analyzes circulating free fatty acids (FFAs) in melanoma patients to...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Chicago a $185,760 Project Grant under the Cancer Research Manpower program (CFDA 93.398) on September 15, 2025, with a completion date of August 31, 2028. The award supports a research project titled "Targeting Glycerol Metabolism in Anti-Tumor Immunity," which investigates the mechanistic relationship between obesity-related metabolic changes and cancer progression, with particular focus on how...
- Federal Project Grant Award Summary The University of Chicago received a $372,628 Project Grant award from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) effective September 12, 2025, with completion targeted for August 31, 2028. This award supports research into spatiomolecular profiling of human cancer at scale, specifically focused on developing and advancing spatially resolved transcriptomics (ST) technologies for analyzing tumor...
- Federal Project Grant Award Summary The University of Chicago received a $464,212 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) awarded on August 1, 2025, with a completion date of July 31, 2030. This five-year project supports research characterizing cancer susceptibility mechanisms associated with the TERT/CLPTM1L locus at chromosome 5p15.33, a highly pleiotropic genetic region linked to increased risk for over 15...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $588,289 Project Grant to the University of Chicago under the Cancer Biology Research program (CFDA 93.396) effective May 1, 2026, through April 30, 2031. This five-year award funds research focused on mechanistically characterizing how BH3 (Bcl-2 homology domain 3) mimetic therapeutics alter T cell function through BCL-2 (B-cell lymphoma-2) family protein interactions. The research aims to advance understanding of...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Chicago a project grant of $169,204.94 under the Cancer Research Manpower program (CFDA 93.398) effective December 1, 2025. This funding supports research investigating how the dietary nutrient zeaxanthin enhances anti-tumor immunity by reprogramming CD8+ T cell function. The research deliverables include preclinical studies demonstrating zeaxanthin's translational potential across multiple...
- Federal Grant Award Summary The National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) awarded the University of Illinois a $412,249 Project Grant effective June 5, 2026, through May 31, 2028, to develop precision liver cancer modeling through CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) editing of primary human hepatocytes. The research addresses critical limitations in current hepatocellular carcinoma (HCC) models by creating a versatile platform that...
- Federal Project Grant Award Summary The University of Chicago received a $651,674 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) for the period June 1, 2026 through May 31, 2031. This award supports the development of a novel radioinducible plug-and-play chimeric antigen receptor T (CAR-T) cell system designed to improve the efficacy of combined radiation therapy and immunotherapy for solid tumors. The research addresses the...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $2,970,010 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded on September 16, 2025, with completion targeted for August 31, 2029. The research initiative focuses on elucidating the tumorigenic mechanisms of somatic truncation mutations in KMT2D, which encodes the histone methyltransferase MLL4 (mixed-lineage leukemia 4), particularly as...
- Federal Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $186,000 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on June 23, 2025, with a completion date of May 31, 2027. The award supports pilot and feasibility studies for NN-01-195, a novel tumor-targeted Aurora-A kinase (AURKA) inhibitor developed through a drug conjugate approach. The research involves preclinical evaluation of this chimeric compound, which fuses an...
The University of Chicago received a $518,151 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) effective July 1, 2026, through June 30, 2031. The award supports research to advance Nicotinamide N-Methyltransferase (NNMT) inhibitor development and investigate mechanisms by which NNMT inhibition can sensitize immunotherapy-resistant tumors to immune checkpoint inhibitors. The research focuses on the tumor microenvironment (TME), specifically targeting cancer-associated fibroblasts (CAFs) in ovarian and colorectal cancers, with the objective of bringing a lead compound (NNMTI'960) to Investigational New Drug (IND)-enabling development status while elucidating how NNMT inhibition reshapes metabolic and epigenetic programs within the TME to enhance anti-PD-1 immunotherapy efficacy. The project deliverables include preclinical research outcomes demonstrating whether NNMT inhibition can restore tumor sensitivity to anti-PD-1 therapy, characterization of metabolic and epigenetic alterations in the TME resulting from pharmacologic NNMT inhibition, and advancement of the small-molecule NNMT inhibitor toward IND-enabling studies. This research builds upon prior collaborative work with the National Center for Advancing Translational Sciences (NCATS) that established NNMTI'960 as a best-in-class inhibitor with robust target engagement and proven efficacy in in vitro and in vivo models.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $518.2k | 6/5/26 |