Project Grant R01CA297773
- This federal Project Grant award of $635,033, provided by the National Cancer Institute (CFDA 93.393 Cancer Cause and Prevention Research program), supports research to understand the genetic basis of a newly recognized cancer-prone syndrome caused by long telomere length. The award was granted to The Johns Hopkins University, a leading federal research contractor, to conduct comprehensive investigations into this genetic mechanism driving cancer development, which is distinct from tumor...
- The federal Project Grant award of $160,330 from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) is supporting research by the University of Illinois to investigate the biochemical determinants of genome instability induced by eukaryotic topoisomerase II. The project aims to determine how the biochemical properties of topoisomerases, along with factors like chromatin structure and DNA repair pathways, influence genome instability. This research builds on the...
- This Project Grant award of $742,391 from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) supports research conducted by Tufts University School of Medicine to develop an in vivo model system that can recapitulate the development and evolution of clonal hematopoiesis (CH) during aging, tumorigenesis, and cancer treatment. CH is a premalignant condition associated with increased risk of hematologic malignancies, particularly in cancer patients undergoing...
- The Cooperative Agreement award titled "CHARACTERIZING GENETIC RISK OF CANCER ACROSS DIVERSE POPULATIONS THROUGH MULTI-ANCESTRY EPIGENOME PROFILING AND CHROMATIN QTL DISCOVERY" is funded by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393). The $720,252 award to the Dana-Farber Cancer Institute aims to identify genetic variants that influence cancer risk regulation across diverse ancestral populations. The project will profile gene...
- The National Cancer Institute (NCI) awarded a $108,512 Project Grant under the Cancer Research Manpower (CFDA 93.398) program to Weill Medical College of Cornell University. The grant supports research to investigate the chromatin landscape of alternative lengthening of telomeres (ALT) in cancer cells. The project aims to: 1) Focus on the role of the ATRX chromatin remodeler in suppressing ALT, using a base editing screen to identify key ATRX domains and functions; and 2) Study the effect of...
- This federal Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program, supports research into the mechanisms that allow telomeres, the ends of chromosomes, to be protected from degradation and fusion that can lead to diseases like cancer. The $999,626 award to The Cleveland Clinic Foundation, commencing on Sep 1, 2025 and concluding on Aug 31, 2028, will investigate the role of the CCQ1 protein in shielding telomeres and...
- The National Cancer Institute (NCI), part of the U.S. Department of Health and Human Services, awarded a $716,623 Cooperative Agreement under the Cancer Cause and Prevention Research program (CFDA 93.393) to the University of Chicago. The award will fund the creation of a multi-tissue DNA methylation data resource using samples from the Genotype-Tissue Expression (GTEx) project. This resource will enable researchers to study variability in human epigenomes and the genetic and environmental...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) supports research by the Stowers Institute for Medical Research to investigate the impact of natural variation in human centromeric DNA sequences and epigenetic patterns on chromosome segregation and genome integrity. The $125,619 grant, awarded on August 1, 2025, will fund research over a 5-year period to map centromeric DNA landscapes and associated kinetochore proteins...
- This federal Project Grant award of $663,340 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to elucidate the mechanisms by which the ablation of intratumoral regulatory T cells can mobilize NK cells and CD4 T cells to control MHC I-deficient tumors. The research aims to determine how CD4 T cell help enhances the antitumor function of NK cells, including the role of cytokines like IL-2 and IL-15, as well as test whether intratumoral Treg depletion...
- This federal Project Grant award of $386,612 from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) will support a research project by the Regents of the University of Minnesota to investigate socioeconomic and environmental factors that contribute to accelerated biological aging, cancer risk, and differences in cancer outcomes among middle-aged and older adults. The project will leverage data from two large prospective studies, the Atherosclerosis Risk in...
This federal Project Grant award of $464,212.00 from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) supports research to characterize the biological mechanisms underlying the pleiotropic effects of genetic variation at the TERT/CLPTM1L locus on cancer susceptibility and aging-related traits. The University of Chicago, the awardee, will integrate large-scale genetic association data, multi-omic quantitative trait loci (QTLs) in stem/differentiating cells, and somatic events across multiple tissue types to elucidate the connections between telomere length, cellular aging, and cancer risk. This 5-year project aims to advance the scientific understanding of how inherited genetic factors at this locus impact a wide range of disease-related phenotypes, with the potential to inform the development of targeted cancer prevention strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $464.2k | 7/30/25 |