Project Grant R01CA312306
- Federal Grant Award Summary Northwestern University received a $2.1 million Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), awarded September 23, 2025, with completion targeted for August 31, 2029. The project aims to determine genotypic, phenotypic, and evolutionary trajectories of treatment resistance to radiotherapy by analyzing matched pre- and post-radiotherapy genomes from patient tissue and patient-derived xenografts (PDXs)...
- Federal Project Grant Summary Northwestern University, through its Sponsored Research Division, received a $1,453,656 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) effective September 1, 2025, with a completion date of August 31, 2030. The grant funds research investigating the role of adverse social-biological interactions in acute myeloid leukemia (AML) disparities. The project leverages the multi-institutional Chicago AML...
- Federal Grant Award Summary Northwestern University received a $495,374 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) on August 25, 2025, with completion targeted for July 31, 2030. The award funds fundamental research investigating the human papillomavirus (HPV) life cycle and the role of R-loops (ribonucleic acid-deoxyribonucleic acid hybrid structures) in viral replication and transcription. The research examines how HPV...
- Federal Grant Award Summary Award Details: Funding Agency: National Cancer Institute Federal Grant Program: Cancer Cause and Prevention Research (CFDA 93.393) Awardee: Northwestern University, Sponsored Research Division Total Obligated Funding: $645,460 Award Period: August 1, 2025 – July 31, 2030 Northwestern University will conduct a five-year research project to elucidate the mechanisms underlying nilotinib-induced artery disease (NIAD) and develop predictive tools to identify patients at...
- Federal Grant Award Summary Northwestern University received a $496,357 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) on April 17, 2026, with a completion date of March 31, 2031. The research aims to investigate and disrupt immunosuppressive mechanisms in glioblastoma (GBM), the most malignant primary brain tumor. The project focuses on understanding how tumor-associated macrophages (TAMs) and glioma cells within the...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $2,970,010 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded on September 16, 2025, with completion targeted for August 31, 2029. The research initiative focuses on elucidating the tumorigenic mechanisms of somatic truncation mutations in KMT2D, which encodes the histone methyltransferase MLL4 (mixed-lineage leukemia 4), particularly as...
- Federal Project Grant Award Summary Northwestern University's Sponsored Research Division received a $631,487 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) effective June 1, 2026, through May 31, 2031. This award supports a comprehensive research initiative investigating the mechanistic underpinnings of LKB1 (STK11) mutation-driven lung cancer and therapeutic resistance mechanisms. The research deliverables include: (1)...
- Federal Project Grant Summary The National Cancer Institute awarded $696,498 to the MGH Institute of Health Professions, Inc. on May 1, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to develop and optimize a multicomponent intervention designed to improve functional recovery and participation in life activities among breast cancer survivors. The project, spanning five years through April 30, 2031, will systematically develop an evidence-based, remotely-delivered...
- Federal Project Grant Summary The University of Michigan, Office of Research and Sponsored Projects, received a $319,505 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) awarded August 1, 2025, with completion by July 31, 2030. This five-year award supports the development of comprehensive nationwide training infrastructure in advanced methodological approaches for constructing and optimizing adaptive interventions across the cancer...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $954,436 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) on September 23, 2025, with a completion date of July 31, 2030. The award funds fundamental cancer research investigating the mechanisms by which chronic myeloid leukemia (CML) leukemia stem cells persist during tyrosine kinase inhibitor (TKI) treatment through their interaction...
Northwestern University received a $544,080 Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), effective June 1, 2026 through May 31, 2031. The award supports the Physical and Functional Improvement via Cancer Rehabilitation Triaging (PIVOT) Trial, which develops and evaluates the 4RS Cancer Rehabilitation Triaging System—an electronic health record-integrated platform designed to identify cancer survivors with physical and functional impairments, match them to appropriate rehabilitation services, and facilitate timely intervention. The project addresses a critical clinical gap where approximately 40% of the 18.1 million U.S. cancer survivors experience physical and functional impairments that remain undertreated due to lack of systematic detection and referral mechanisms. The primary deliverable is a two-arm randomized controlled trial conducted across Northwestern Medicine oncology clinics to evaluate the clinical and implementation outcomes of the 4RS system compared to usual care. The research will enroll 1,000 cancer survivors with impairments identified within three months of diagnosis and track participants over a two-year period. By embedding systematic monitoring and triaging into routine oncology care, the 4RS platform aims to reduce clinician burden while supporting early intervention and patient self-management capabilities, ultimately reducing avoidable disability and improving health-related quality of life outcomes for cancer survivors.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $544.1k | 6/1/26 |