Project Grant R01CA295560
- This $732,000 Project Grant from the National Cancer Institute, part of the Department of Health and Human Services, will support research under the Cancer Treatment Research program. The grant recipient, Northwestern University, will develop a bridge-lipid nanoparticle platform to reprogram immunosuppressive tumor-associated myeloid cells and potentiate radiotherapy for glioblastoma. Over a five-year period, the university will conduct three aims: harnessing myeloid cells to phagocytose...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $2.1 million Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) awarded on September 23, 2025, with a completion date of August 31, 2029. The award supports translational research to determine genotypic, phenotypic, and evolutionary trajectories of treatment resistance to radiotherapy, addressing a critical gap in personalized cancer...
- Federal Project Grant Award Summary Northwestern University's Sponsored Research Division received a $954,436 project grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective September 23, 2025, with a completion date of July 31, 2030. This award funds fundamental research investigating the persistence of leukemia stem cells (LSCs) in chronic myeloid leukemia (CML) patients during tyrosine kinase inhibitor (TKI) treatment, with...
- Federal Grant Award Summary Award Details: Funding Agency: National Cancer Institute Federal Grant Program: Cancer Cause and Prevention Research (CFDA 93.393) Awardee: Northwestern University, Sponsored Research Division Total Obligated Funding: $645,460 Award Period: August 1, 2025 – July 31, 2030 Northwestern University will conduct a five-year research project to elucidate the mechanisms underlying nilotinib-induced artery disease (NIAD) and develop predictive tools to identify patients at...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Illinois a $386,279 Project Grant on July 10, 2025, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop innovative immunotherapy screening capabilities. The grant funds the creation of a microfluidic device cassette and associated functional immune assay protocols designed to enable personalized immunotherapy screening directly on core needle biopsies from cancer patients. This...
- Federal Grant Award Summary The National Cancer Institute awarded a $663,340 Project Grant to the University of California, Berkeley on August 27, 2025, under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research on regulatory T cell-mediated suppression of tumor elimination. The research will elucidate mechanisms by which local ablation of intra-tumoral regulatory T cells (IT-Tregs) mobilizes natural killer (NK) cells and CD4 T cells to control tumors that have...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $185,760 to the University of Chicago under the Cancer Research Manpower program (CFDA 93.398) on September 15, 2025, for a research project titled "Targeting Glycerol Metabolism in Anti-Tumor Immunity." The award supports a three-year project (concluding August 31, 2028) investigating the mechanistic relationship between glycerol metabolism and CD8+ T cell function in the context of obesity-related...
- Summary of Federal Grant Award Northwestern University, through its Sponsored Research Division, received a $1.45 million Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), effective September 1, 2025, through August 31, 2030. This research project investigates the role of adverse social-biological interactions in acute myeloid leukemia (AML) disparities, examining how sociodemographic characteristics and neighborhood...
- Federal Grant Award Summary The National Cancer Institute awarded University of California, Irvine a $648,626 Project Grant on April 2, 2026, under the Cancer Treatment Research program (CFDA 93.395) to investigate the mechanisms of immunosuppression triggered by checkpoint blockade immunotherapy (CBI). The research, which runs through March 31, 2031, addresses a critical gap in cancer immunotherapy by examining why PD-1 (programmed death receptor 1) blockade and dual checkpoint inhibitor...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Washington University a Project Grant totaling $2.47 million under the Cancer Biology Research program (CFDA 93.396) on August 18, 2025, with completion targeted for July 31, 2029. This grant supports fundamental research investigating the role of wild-type isocitrate dehydrogenase 1 (WT-IDH1) metabolism in reprogramming the tumor microenvironment of glioblastoma. The research encompasses both in vitro and in...
The National Cancer Institute awarded Northwestern University a $496,357 Project Grant effective April 17, 2026, under the Cancer Treatment Research program (CFDA 93.395) to support research aimed at disrupting immunosuppression mechanisms in glioblastoma (GBM). The research deliverables include investigations into the tumor microenvironment dynamics during necrotic phase transitions, utilizing patient-derived GBM neurosphere cultures and murine models with advanced spatial transcriptomics capabilities. The project will generate mechanistic insights into tumor-associated macrophage (TAM) polarization within the peri-necrotic niche, with specific focus on the PDPN-CLEC5A-SYK signaling pathway and its role in sustaining immunosuppression. The grant supports research activities extending through March 31, 2031, with anticipated deliverables including preclinical efficacy data on SYK inhibitor treatment combined with standard chemoradiation and checkpoint immunotherapy in GBM models. Products and findings are expected to contribute to improved therapeutic strategies for this highly aggressive primary brain malignancy by identifying molecular targets that diminish TAM-mediated immunosuppression and enhance CD8+ T cell infiltration within the tumor microenvironment. Research will be conducted at Northwestern University's Chicago facility under the Cancer Treatment Research program, which funds fundamental and applied laboratory and clinical research supporting the discovery and development of improved cancer treatment methodologies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $496.4k | 4/17/26 |