Project Grant R01CA311706
- Federal Grant Award Summary New York University School of Medicine received a $695,852 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) awarded May 1, 2026, with completion scheduled for April 30, 2031. The research investigates T cell circuits within the lymphatic system during melanoma progression, specifically examining tumor-draining lymph nodes (TDLNs) as critical hubs for anti-tumor immune surveillance. The project focuses on...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded New York University School of Medicine a $716,681 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective May 22, 2026, through April 30, 2031. This award funds research to understand and therapeutically target myeloid sarcoma (MS), a rare and aggressive subtype of acute myeloid leukemia (AML) occurring in approximately 5-10% of patients. MS is characterized by poor survival outcomes with a 5-year...
- Federal Project Grant Award Summary Funding Agency: National Cancer Institute (NCI) Program: Cancer Research Manpower (CFDA 93.398) Award Amount: $149,190 Award Date: December 1, 2025 Completion Date: May 6, 2027 Recipient: New York University School of Medicine New York University School of Medicine received $149,190 in federal project grant funding from the National Cancer Institute to support research training and workforce development in cancer biology. The award funds biomedical training...
- Federal Grant Award Summary New York University School of Medicine received a $585,482 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) awarded June 1, 2026, with completion targeted for May 31, 2031. This research grant funds fundamental investigation into the molecular mechanisms of breast cancer metastasis, specifically examining the role of the translation factor DAP5 (Death-Associated Protein 5) in selective messenger ribonucleic...
- Federal Project Grant Award Summary New York University School of Medicine received a $315,246 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective August 1, 2025, through July 31, 2030. This five-year research initiative, titled "Breaking Cytokine Loops in Lung Adenocarcinoma," will deliver fundamental cancer research and scientific investigation focused on understanding immune resistance mechanisms in lung cancer...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $418,176.00 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) for the period September 1, 2025, through August 31, 2028. This three-year award supports the advanced development and validation of programmable nucleic acid cytometry, a technology designed to isolate and profile rare cell populations from tumors and tissues. Building on the...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $495,715 to the Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) on August 5, 2025, with a completion date of July 31, 2030. This award funds fundamental research to decipher the pathogenesis and therapeutic vulnerabilities in germline RUNX1-mutated acute myeloid leukemia (AML). The research focuses on understanding how germline RUNX1 mutations...
- Federal Project Grant Award Summary New York Institute of Technology received a $459,000 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) for the period July 1, 2025 through June 30, 2028. The award funds fundamental research investigating the critical role of the microRNA 34/449 family in choroid plexus (CP) differentiation and tumorigenesis. The research utilizes experimental models to elucidate the biological mechanisms underlying CP...
- Federal Project Grant Award Summary The National Cancer Institute awarded $1,034,176 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) on August 18, 2025, for a project extending through July 31, 2032. The research focuses on understanding and targeting aberrant RNA splicing in leukemia, building on the principal investigator's 13-year track record of discovering genetic alterations in hematopoietic malignancies. The project aims to...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $2.68 million Project Grant under the Cancer Biology Research program (CFDA 93.396) to Icahn School of Medicine at Mount Sinai, with an award date of August 1, 2025, and a completion date of July 31, 2030. This five-year research initiative, led by Principal Investigator James Manfredi, investigates mutant p53 protein's role in tumorigenesis, invasion, and metastasis. The program comprises four integrated...
New York University School of Medicine received a $684,529 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective July 1, 2026 through June 30, 2031. This fundamental cancer biology research project investigates SHP2 (PTPN11) signaling mechanisms, focusing on understanding how this protein-tyrosine phosphatase functions as a positive regulator of receptor tyrosine kinase (RTK) signaling pathways. The research addresses critical knowledge gaps regarding SHP2's role in RAS pathway activation, the distinct functions of its phosphatase domain and tyrosine phosphorylation sites, and the conformational requirements of its catalytic domain independent of enzymatic activity. The award supports an integrated research program employing super-resolution microscopy and other advanced techniques to elucidate SHP2's molecular mechanisms in both biochemical systems and murine models. Findings are expected to advance understanding of Noonan Syndrome and related rasopathies caused by germline PTPN11 mutations, as well as inform development of therapeutic strategies including the allosteric SHP2 inhibitors currently in clinical trials. The research contributes to the NCI's broader mission of providing fundamental information on cancer biology that may improve prevention, detection, diagnosis, and treatment of neoplastic diseases, with particular relevance to cancer cell biology and structural biology with molecular applications.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $684.5k | 6/30/26 |