Project Grant R01CA311048
- Federal Grant Award Summary Baylor College of Medicine received a $160,000 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded May 1, 2026, with completion targeted for April 30, 2028. The grant funds research aimed at dissecting the metabolic rewiring mediated by SMARCB1 (Switch/Sucrose Non-Fermentable-related, Matrix-associated, Actin-dependent Regulator of Chromatin, Subfamily B, Member 1) loss in metastatic bladder cancer....
- Federal Grant Award Summary Baylor University received a $545,000 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective May 1, 2026, through April 30, 2029. The award supports fundamental research investigating tumor cell autonomous and non-autonomous mechanisms of Lipocalin-2 (LCN2) function in solid tumor metastasis. The research will employ single-cell spatial proteomic and transcriptomic analyses to determine how LCN2...
- Federal Grant Award Summary Baylor College of Medicine received a $160,500 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective July 10, 2025, with completion targeted for June 30, 2027. The award funds the development and investigation of in vivo murine models to examine the role of caspase-2 in nucleophosmin-mutated acute myeloid leukemia (NPM1C+ AML). The research deliverables include the establishment of transgenic mouse...
- Federal Project Grant Award Summary Baylor College of Medicine received a $411,404 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) awarded on August 20, 2025, with a completion date of July 31, 2027. This research initiative aims to identify genes with a significant deficit of loss-of-function (LOF) mutations in lung tumors, a novel approach to cancer-related gene identification. The project utilizes statistical regression modeling and...
- Federal Grant Award Summary Health Research, Inc. (Roswell Park Division) received a $639,379 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective May 1, 2026, through April 30, 2031. The award supports the development and validation of neuroendocrine bladder carcinoma (NEBC) models to advance translational cancer research in response to PAR-24-306. The project addresses a critical unmet clinical need by developing complementary...
- Federal Grant Award Summary Baylor College of Medicine received $882,470 in funding from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) for a five-year project period beginning September 1, 2025, and concluding August 31, 2030. Under this NCI Research Specialist (Clinician Scientist) Award, the institution will deliver clinical trial leadership and research coordination services focused on pediatric and adolescent cancer care, particularly for...
- Federal Grant Award Summary Baylor College of Medicine received a $2.4 million Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective August 15, 2025 through July 31, 2029. The award funds research investigating the role of RNA sequestration in acute myeloid leukemia (AML), specifically examining how the RNA helicase DDX6 (DEAD-Box Helicase 6) regulates post-transcriptional processes critical to leukemia development and...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Institute For Cancer Research a Project Grant totaling $766,439 (awarded April 1, 2026, with completion targeted for March 31, 2031) under the Cancer Cause and Prevention Research program (CFDA 93.393). This research project focuses on intratumor heterogeneity as a correlate of clinical outcomes in bladder cancer patients seeking to avoid radical cystectomy. The research addresses the critical clinical need for...
- Federal Project Grant Award Summary Baylor University received a $300,002 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), awarded September 4, 2025, with a completion date of August 31, 2029. The project titled "Graph-String Transformer and Reinforcement Learning for Design of Cancer Theranostics" aims to develop an artificial intelligence (AI)-driven approach for accelerating the discovery of dual-targeted...
- Federal Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $483,395 Project Grant under the Cancer Treatment Research program (CFDA 93.395) beginning September 1, 2025, and concluding August 31, 2027. This research initiative focuses on investigating P300 and CBP (Cyclic AMP-Response Element Binding Protein) as novel therapeutic targets in renal cell carcinoma (RCC), specifically clear cell RCC (ccRCC). The project will examine the therapeutic potential...
Baylor College of Medicine received a $681,330 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective May 13, 2026, through April 30, 2031. This five-year research initiative focuses on dissecting the mechanisms of ephox epoxide hydrolase 2 (EPHX2)-deficient bladder cancer and identifying metabolic and immunologic vulnerabilities to enable precision medicine approaches. The research program delivers comprehensive scientific analysis integrating transcriptomic, proteomic, and metabolomic datasets from bladder cancer patient tumors to characterize molecular subtypes and develop targeted therapeutic strategies. Key research activities include investigating EPHX2 gene deletions observed in over 50% of bladder cancer cases, analyzing the accumulation of epoxyeicosatrienoic acids (EETs) resulting from EPHX2 deficiency, and evaluating the AKT-PKN3 signaling axis and NECTIN4 upregulation as therapeutic targets for improved patient outcomes. The deliverables from this project contribute to advancing cancer treatment methodology through fundamental laboratory research and identification of novel intervention points for aggressive bladder cancer subtypes. By establishing the tumor-suppressive role of EPHX2 and characterizing associated metabolic pathways, the research aims to guide development of improved therapeutic methods and control disease progression in patients who do not respond to standard therapies, directly supporting the Cancer Treatment Research program's objective to develop means to cure cancer patients and control disease through discovery and development of novel treatment approaches.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $681.3k | 5/14/26 |