Project Grant R03CA297346
- Federal Project Grant Award Summary Baylor College of Medicine received a $411,404 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) on August 20, 2025, with a completion date of July 31, 2027. The grant supports fundamental research aimed at identifying cancer-essential genes through analysis of loss-of-function (LOF) mutations in lung tumors. Specifically, the research applies statistical regression modeling to identify genes...
- Federal Grant Award Summary Baylor College of Medicine received a $160,500 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective July 10, 2025, with completion targeted for June 30, 2027. The award funds the development and investigation of in vivo murine models to examine the role of caspase-2 in nucleophosmin-mutated acute myeloid leukemia (NPM1C+ AML). The research deliverables include the establishment of transgenic mouse...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Institute For Cancer Research a Project Grant of $766,439 under the Cancer Cause and Prevention Research program (CFDA 93.393) for the period April 1, 2026 through March 31, 2031. This research project focuses on intratumor heterogeneity as a correlate of clinical outcomes in bladder cancer patients pursuing cystectomy avoidance strategies. The primary deliverables include: (1) scientific investigation into the genetic...
- Federal Project Grant Award Summary Baylor College of Medicine received a $483,077 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective June 1, 2025 through May 31, 2030. The award supports fundamental research investigating three-dimensional circadian enhancer-promoter interactions mediated by estrogen-related receptor gamma (ESRRG) in the progression from nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC)....
- Federal Grant Award Summary Baylor University received a $545,000 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) awarded May 1, 2026, with completion targeted for April 30, 2029. The research project investigates tumor cell autonomous and non-autonomous mechanisms of Lipocalin-2 (LCN2) function in metastasis, addressing a significant gap in understanding how LCN2 promotes solid tumor progression across primary, premetastatic, and...
- Federal Grant Award Summary Baylor College of Medicine received a $147,486 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) effective December 1, 2025, through April 20, 2027. The award supports research and development of RECON (Recombinant Element Control), a novel immune tolerization strategy designed to investigate the relationship between oncogene pathogenicity and immunogenicity in early-stage cancer development. RECON enables...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $168,000 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), effective July 1, 2025, with completion scheduled for June 30, 2027. The award funds research to examine risk factors and develop predictive models for multiple recurrences of non-muscle invasive bladder cancer (NMIBC). The research leverages existing demographic, lifestyle,...
- Federal Grant Award Summary Health Research, Inc. at Roswell Park received a $639,379 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) beginning May 1, 2026, with a completion date of April 30, 2031. The award funds research to develop and validate neuroendocrine bladder carcinoma (NEBC) models for translational research, addressing the critical need to understand NEBC pathogenesis and overcome chemotherapy resistance. The project...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The University of Texas MD Anderson Cancer Center a $2.1 million Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) effective September 1, 2025, through August 31, 2030. This P01 (Program Project) grant funds a multi-institutional research initiative focused on elucidating the mechanisms of bladder cancer development and identifying therapeutic vulnerabilities to preventive and interventive...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Baylor College of Medicine a $882,470 Research Specialist (Clinician Scientist) Award under the Cancer Treatment Research program (CFDA 93.395) for the period September 1, 2025 through August 31, 2030. This Project Grant supports the expansion of leadership in the design and conduct of NCI-funded clinical trials for children, adolescents, and young adults with cancer, with particular focus on hematologic malignancies. The...
Baylor College of Medicine received a $160,000 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective May 1, 2026 through April 30, 2028. The award funds fundamental research aimed at understanding metabolic pathway alterations mediated by SMARCB1 (Switch/Sucrose Non-Fermentable Related Matrix-Associated Actin-Dependent Regulator of Chromatin, Subfamily B, Member 1) loss in metastatic bladder cancer. The research addresses a critical clinical need, as over 60% of bladder cancer cases harbor alterations in SWI/SNF nucleosome remodeling complex subunits, yet current standard-of-care therapies demonstrate relatively low response rates. The project deliverables include comprehensive characterization of metabolic rewiring in SMARCB1-deficient bladder cancer tumor cells and tumor-infiltrating immune cells, as well as identification and validation of key metabolic pathways amenable to therapeutic intervention. Using advanced high-resolution mass spectrometry techniques and stable isotope tracing in orthotopic mouse models, the research will examine altered methionine metabolism, nucleotide synthesis, and glutathione metabolism pathways. The ultimate objective is to identify druggable metabolic targets that may enhance treatment efficacy for metastatic bladder cancer patients with SMARCB1 loss, thereby contributing to improved prevention, detection, and therapeutic strategies in neoplastic disease management.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $160.0k | 4/17/26 |