Project Grant R01CA304705
- Federal Grant Award Summary The National Cancer Institute awarded $125,619 to the Stowers Institute for Medical Research under the Cancer Cause and Prevention Research program (CFDA 93.393) effective August 1, 2025, through July 31, 2030. This Project Grant supports research into centromere biology and chromosome segregation mechanisms that contribute to genomic instability—a hallmark of cancer development. The primary deliverables include experimental research characterizing how natural...
- Federal Grant Award Summary The Salk Institute for Biological Studies received a $130,501 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded on July 9, 2025, with completion anticipated by June 30, 2027. This research initiative focuses on elucidating the transcriptional regulation of cyclin-dependent kinase inhibitor 1A (CDKN1A) in muscle tissue and developing novel therapeutic strategies to combat cancer cachexia—a...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $182,755.00 to Cold Spring Harbor Laboratory through the Cancer Biology Research program (CFDA 93.396) to support research on genetic technology development for elucidating lineage plasticity mechanisms in cancer. The project, which commenced on August 21, 2025, and is scheduled for completion on July 31, 2030, will deliver advanced genetic screening technologies and methodologies designed to probe lineage identity...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $418,176.00 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) for the period September 1, 2025, through August 31, 2028. This three-year award supports the advanced development and validation of programmable nucleic acid cytometry, a technology designed to isolate and profile rare cell populations from tumors and tissues. Building on the...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $323,860 Project Grant to Sloan-Kettering Institute for Cancer Research under the Cancer Research Manpower program (CFDA 93.398) on August 18, 2025, with completion targeted for April 30, 2028. This award supports research investigating the role of mutagenic DNA repair pathways in cancer cell persistence and acquired drug resistance. The project focuses on understanding how cancer cells under stress from anti-cancer...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $733,864 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the Beckman Research Institute of the City of Hope, effective June 1, 2026, through May 31, 2031. This five-year research initiative focuses on identifying and characterizing stimulatory immune checkpoints that regulate macrophage-mediated programmed cell removal (PRCR) in tumor immunosurveillance. Using high-throughput CRISPR-based screening...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded $730,097 to the Sloan-Kettering Institute for Cancer Research under the Cancer Treatment Research program (CFDA 93.395) for a five-year project period from May 1, 2026 through April 30, 2031. This Project Grant supports fundamental research aimed at understanding and overcoming chronic inflammation-driven T cell quiescence in gastric adenocarcinoma. The research team will conduct single-cell genomic profiling and analysis of...
- Federal Project Grant Award Summary The National Cancer Institute awarded $292,028 to Sloan-Kettering Institute for Cancer Research under the Cancer Research Manpower program (CFDA 93.398) beginning August 1, 2025, and concluding July 31, 2030. This five-year Project Grant supports research investigating genome instability associated with focal oncogene amplification (OA) and the development of therapeutic strategies to address treatment-resistant cancers. The research deliverables include...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Sloan-Kettering Institute for Cancer Research a $3.2 million Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) beginning August 1, 2025, and concluding July 31, 2029. This research initiative investigates the mechanisms of extrachromosomal DNA (ecDNA) segregation and repair in cancer cells, with emphasis on understanding how ecDNA's circular topology contributes to tumor progression...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under the Cancer Biology Research program (CFDA 93.396), awarded Columbia University's Health Sciences Division a $501,422 Project Grant effective May 1, 2026, through April 30, 2031, to advance research on synthetic lethal (SL) targeting in cancer. This research builds upon the institution's established expertise in identifying and characterizing SL drug targets and seeks to validate and mechanistically characterize the...
The National Cancer Institute (NCI) awarded The Salk Institute for Biological Studies a $795,143 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) on May 4, 2026, with a completion date of April 30, 2031. This research initiative aims to identify chromatin regulators that facilitate enhancer hijacking in cancer genomes—a mechanism where structural variants cause non-cognate enhancers to aberrantly activate oncogenes. Through this funding, the Salk Institute will conduct CRISPR/Cas9 genome-wide knockout screens and mechanistic studies to investigate the regulatory balance between STAG1 and STAG2 cohesin complex components, with the objective of uncovering potential therapeutic targets applicable across diverse cancer types. The research addresses a significant gap in understanding cancer genomic instability by examining how promiscuous gene regulation occurs in cancer-specific enhancer hijacking events. Preliminary findings indicate that STAG1 promotes enhancer hijacking while STAG2 represses it, suggesting that the balance of these mutually exclusive cohesin components may regulate ectopic gene expression in cancer. The deliverables from this five-year project will include scientific findings on chromatin regulation mechanisms, identification of therapeutic targets, and contributions to the broader understanding of oncogene dysregulation across multiple cancer types.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $795.1k | 5/5/26 |