Project Grant R01CA304551
- Federal Grant Award Summary The National Cancer Institute awarded a $736,168 Project Grant to Sloan-Kettering Institute for Cancer Research (award date: August 1, 2025; completion date: July 31, 2030) under the Cancer Treatment Research program (CFDA 93.395) to develop novel antibody-drug conjugates (ADCs) and antibody-oligonucleotide conjugates (AOCs) designed to enhance radiotherapy efficacy through antigen-specific radiosensitization. The research focuses on delivering potent DNA damage...
- Federal Grant Award Summary The National Cancer Institute awarded Sloan-Kettering Institute for Cancer Research a $644,423 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on June 18, 2026, with a completion date of May 31, 2031. This award supports the development and evaluation of short-wave infrared (SWIR) Cerenkov luminescence imaging (CLI) technology to improve visualization and monitoring of targeted radiotherapy agents and diagnostic radiotracers. The research...
- Federal Grant Award Summary The National Cancer Institute awarded Brigham and Women's Hospital a $711,696 Project Grant under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) for the period July 1, 2026 through June 30, 2031. The award supports the modernization and modularization of 3D Slicer, a free, open-source software platform for advanced medical imaging analysis. The project will rearchitect 3D Slicer's core architecture into logical, reusable building block packages...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $418,176.00 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) for the period September 1, 2025, through August 31, 2028. This three-year award supports the advanced development and validation of programmable nucleic acid cytometry, a technology designed to isolate and profile rare cell populations from tumors and tissues. Building on the...
- Federal Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a $584,521 Project Grant on August 8, 2025, under the Cancer Treatment Research program (CFDA 93.395) to investigate subclonal determinants of radiation response in soft tissue sarcomas. The research will deliver three primary products: (1) identification and validation of epigenetic changes, including DNA methylation and chromatin accessibility alterations, that confer radioresistance to...
- Federal Grant Award Summary The National Cancer Institute awarded Sloan-Kettering Institute for Cancer Research a $452,540 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) on July 11, 2025, with a completion date of June 30, 2027. This award supports the development of a novel T-cell imaging paradigm utilizing positron emission tomography (PET) agents targeting CD8 and CD4 markers to provide real-time monitoring of endogenous T-cell trafficking, tumor...
- Federal Grant Award Summary The National Cancer Institute awarded Sloan-Kettering Institute for Cancer Research a $693,290 Project Grant under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) effective May 1, 2026, through April 30, 2031. This award supports research to identify spatial tumor microenvironment (TME) signatures for risk stratification in primary melanoma. The project will deliver whole-slide multiplex immunofluorescence (MIF) tissue imaging analysis of 450 stage...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $495,715 to the Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) on August 5, 2025, with a completion date of July 31, 2030. This award funds fundamental research to decipher the pathogenesis and therapeutic vulnerabilities in germline RUNX1-mutated acute myeloid leukemia (AML). The research focuses on understanding how germline RUNX1 mutations...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $323,860 Project Grant on August 18, 2025, to Sloan-Kettering Institute for Cancer Research under the Cancer Research Manpower program (CFDA 93.398) to support biomedical research training and investigator development in cancer science. The project, titled "Investigating the Role of Mutagenic DNA Repair During the Persistence of Cancer Cells," will be conducted at the Institute's New York facility through April...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $730,398 to Sloan-Kettering Institute for Cancer Research through the Cancer Treatment Research program (CFDA 93.395) on September 1, 2025, for a five-year project period concluding August 31, 2030. This Project Grant supports research and development activities designed to advance novel treatment approaches for rectal cancer, with emphasis on organ preservation strategies that minimize patient morbidity. The...
The National Cancer Institute awarded a Project Grant of $676,849 to the Sloan-Kettering Institute for Cancer Research under the Cancer Treatment Research program (CFDA 93.395) to substantially enhance MIRDSOFT.org, an open-source radiation dosimetry platform. The award, effective July 1, 2026 through June 30, 2031, supports the development of enhanced dosimetry software and computational tools to enable personalized dose estimation in nuclear medicine and radiology. Key deliverables include the creation of an extensive computational human phantom library comprising over 750 mesh-type phantoms representing diverse human body morphometry, refinement of mouse and rat phantom libraries for preclinical dosimetry applications, and advancement of model-based tumor phantoms to address current limitations in tumor dosimetry assessment. These products will be integrated into MIRDCALC (internal dosimetry software) and MIRDCT (CT dosimetry software) components of the MIRDSOFT platform to provide researchers, clinicians, industry professionals, and regulators with free, rigorously evaluated tools for optimizing therapeutic efficacy while minimizing adverse effects. The initiative aligns with the Cancer Treatment Research program's objectives to develop improved cancer treatment methods and addresses the growing demand for tailored dosimetric approaches in precision medicine through a multidisciplinary bioengineering approach.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $676.8k | 6/10/26 |