Project Grant R01CA304244
- This $632,300 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to develop an integrated ultra-high-throughput 3D volumetric super-resolution imaging system for studying the tumor microenvironment. The project, led by Carnegie Mellon University, will combine a multiscale fluorescence mesoscope with expansion microscopy to enable rapid, large-area 3D imaging at the subcellular level. This innovative system will allow researchers to visualize...
- This $449,726 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development of innovative tools to enable the rapid, high-sensitivity mapping of changes in protein interactions within living cells. The University of Illinois is the primary awardee and will leverage advanced biotinylation techniques, including light-regulated and engineered biotin ligases, to facilitate the real-time analysis of dynamic changes in protein...
- This Project Grant award, valued at $424,734 and provided by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research), supports the development of a novel spatial proteomics approach to analyze the tumor microenvironment. The University of Illinois, the award recipient, will integrate 3D microscopy techniques with bottom-up proteomic assays to profile the proteomes of specific immune cells within different subregions of a mouse tumor. This innovative methodology aims to...
- This $372,628 Project Grant was awarded by the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) to the University of Chicago on September 12, 2025. The grant supports the development of a large-format spatially resolved transcriptomics (ST) profiling platform called Array-SEQ, which aims to enable detailed spatiomolecular analyses of cancer samples across a large number of patient cohorts. The project seeks to overcome key limitations of existing ST technologies,...
- The federal Project Grant award of $306,872 from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports the development of a new "Multi-Camera Array Scanner" (MCAS) imaging system by Ramona Optics Inc. The MCAS is designed to rapidly digitize and automatically analyze 3D fine-needle aspiration cytology slides, which are a critical first step in the cancer diagnosis pipeline. This technology aims to enable real-time assessment of specimen adequacy and provide...
- This federal Project Grant award of $670,534 from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) supports the development of an optical hyperspectral nanoscale chromatin analysis technology for the risk-stratification of colorectal cancer (CRC). The goal is to create a screening test that can accurately identify patients with advanced adenomas, who should then undergo colonoscopy. The project aims to leverage field carcinogenesis and chromatin...
- This federal Project Grant award of $400,000 from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) is funding the development of a Mini-Reflectance Confocal Microscope (Mini-RCM) to aid in skin cancer diagnosis and treatment. The project aims to create a low-cost, non-invasive microscopy tool that can provide real-time cellular-level imaging of skin lesions, as an alternative to the current invasive and time-consuming biopsy process. The award was...
- This federal Project Grant award of $568,151 from the National Cancer Institute (CFDA 93.394 Cancer Detection and Diagnosis Research) is supporting the development of a real-time photoacoustic imaging platform to accurately detect and characterize prostate cancer aggressiveness. The project, led by the Regents of the University of Michigan, aims to leverage advanced photoacoustic imaging and biocompatible hydrogel nanoparticle probes to quantitatively assess prostate gland microarchitecture...
- This $635,749 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development and validation of a new atomic force microscopy (AFM)-based technology to simultaneously measure the adhesive properties and physicochemical surface composition of live cells. The goal is to create a system capable of analyzing "dispersive adhesion" based on van der Waals interactions, which is particularly relevant for invasive cells like circulating...
- The National Cancer Institute (NCI) awarded a Project Grant of $2,284,054 to the Regents of the University of Michigan under the Cancer Detection and Diagnosis Research program (CFDA 93.394). The grant, titled "DEEPSRH: Transforming Molecular Cancer Screening with Stimulated Raman Histology and Deep Neural Networks," aims to develop novel approaches for early cancer detection and diagnosis through cutting-edge technologies such as molecular analysis, biomarker discovery, and advanced...
This $573,470 federal Project Grant award from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) is supporting the "Development of Nanoscale Infrared Spectroscopic Imaging for Measuring Cellular Ultrastructure" at the University of Illinois. The project aims to develop a new Atomic Force Microscope-Infrared (AFM-IR) imaging technology, called Resonance Enhance Null-Deflection IR (RENDIR) Spectroscopic Imaging, to enable label-free, nanoscale chemical imaging of biological materials. The award period is from August 25, 2025 to July 31, 2030. The new RENDIR technology is expected to overcome limitations of current AFM-IR systems, allowing for improved accuracy, precision, and sensitivity in analyzing small molecules and cellular ultrastructure without requiring labeling techniques. This research has the potential to significantly advance cancer screening, diagnostic technologies, and early detection methodologies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $573.5k | 8/22/25 |