Project Grant R01CA301721

Award Date 4/8/25
Completion Date 3/31/28
Dollars Obligated $768K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
California, USA
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The research will implement high-throughput screening assays developed by the institute to identify small molecules that can selectively inhibit SGF29 activity. Promising compound hits will then undergo further secondary and tertiary validation testing to confirm their potency and selectivity. Ultimately, the most potent and selective SGF29 inhibitors will be evaluated for their ability to impair leukemogenesis in AML cell lines and patient samples, as well as their impact on normal hematopoietic cells. This work aims to uncover a novel class of anti-AML therapeutic compounds targeting a common molecular pathway dysregulated across diverse AML subtypes.

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