Project Grant R01CA301382
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $639,514 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective June 1, 2026, through May 31, 2031. This five-year research initiative funds mechanistic characterization studies of benzothiazepinone compounds, specifically MM17, which inhibit NVL (a critical AAA+ adenosine triphosphatase enzyme involved in ribosomal subunit...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $1.29M project grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), awarded September 1, 2025, with completion targeted for August 31, 2028. The project develops advanced imaging and analysis tools to enhance lymphoscintigraphy (LSG), the current gold...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $680,129 Project Grant to The University of Texas MD Anderson Cancer Center for the Cancer Treatment Research program (CFDA 93.395) beginning April 1, 2026 and concluding March 31, 2031. This award funds the development of drug-loaded degradable biopolymeric scaffolds designed to augment preoperative liver growth in hepatic surgery patients. The project addresses critical clinical needs by developing a controlled...
- Federal Project Grant Award Summary Case Western Reserve University received $630,108 in Project Grant funding from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded March 13, 2026, with a completion date of February 28, 2030. The award supports theranostic research developing combined fluorescence image-guided surgery (FIGS) and photothermal therapy (PTT) approaches for breast cancer treatment. The research centers on optimizing...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $402,011 Project Grant to The University of Texas Southwestern Medical Center under the Cancer Biology Research program (CFDA 93.396) effective May 1, 2026, through April 30, 2031. This five-year research initiative investigates the molecular mechanisms by which the KEAP1-NRF2 redox-sensing pathway regulates CD8 T cell adaptation to chronic antigen receptor signaling in cancer and chronic infection contexts. The research...
- Federal Grant Award Summary The University of Texas at Austin received a $668,878 Project Grant awarded on April 3, 2026, by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) to develop a novel antibody-drug conjugate (ADC) platform targeting CD44 variant 9 (CD44V9) for aggressive and treatment-resistant breast cancer. The research will deliver two key technical innovations: (1) development of conditionally-active antibodies engineered to enhance binding...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Texas at Austin a $2.59 million Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective August 1, 2025, through July 31, 2029. The award supports research to develop a novel cancer immunotherapy approach targeting immune-excluded or "cold" tumors that typically demonstrate poor response to immune checkpoint therapy. The project focuses on demonstrating that degradation of...
- Federal Project Grant Summary The National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) awarded $683,885 to The University of Texas Southwestern Medical Center on May 1, 2026, for a five-year project concluding April 30, 2031. The award funds the development of the first clinical prototype for proton minibeam radiation therapy (PMBRT), an advanced spatially fractionated radiation therapy modality designed to improve upon conventional radiation therapy by delivering a highly...
- Federal Project Grant Award Summary Oregon Health & Science University received a $2.49 million Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) on August 15, 2025, with a completion date of July 31, 2029. The award supports development and validation of fluorescence-guided surgery (FGS) technology to enable real-time nerve visualization during colorectal cancer surgical procedures. The project addresses a...
- Federal Project Grant Award Summary The University of Texas Health Science Center at Houston received a $663,818 Project Grant award effective May 1, 2026, through April 30, 2031, from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395). This research initiative will assess the impact of early physiotherapy interventions on lymphatic dysfunction in breast cancer survivorship. The project will utilize advanced near-infrared fluorescence lymphatic imaging...
The University of Texas Southwestern Medical Center received a $623,432 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) to advance fluorescence-guided surgery (FGS) technology for cancer resection. Awarded on May 7, 2026, with a completion date of April 30, 2031, this academic-industrial partnership project focuses on developing an enhanced Cancer Vision Goggle (CVG) system—a head-mounted imaging device designed to reduce positive margin rates in head and neck cancer and breast cancer surgeries by providing real-time fluorescence visualization of cancerous tissue during surgical procedures. The project deliverables include three primary technological enhancements to the existing CVG platform: transitioning from monocular to stereoscopic vision to improve tissue contour visualization and spatial alignment; integrating intraoperative ultrasound capabilities to address subsurface tumor detection limitations prior to incision; and augmenting the system with external exoscope microscopic imaging functionality. These improvements are intended to broaden the CVG's clinical applicability across multiple cancer types and non-cancerous surgical procedures, addressing critical gaps identified by collaborative surgeons during preclinical and clinical testing phases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $623.4k | 5/12/26 |