The National Cancer Institute (NCI) awarded a 5-year, $709,554 Project Grant (CFDA 93.395 - Cancer Treatment Research) to Emory University to advance the understanding of how a novel neoadjuvant therapy impacts the immune system in patients with solid tumors, using refractory melanoma as a model. The key objectives are to: Gain insights on how blocking the Semaphorin 4D (SEMA4D) protein, when combined with immune checkpoint blockade, affects the induction and infiltration of antigen-presenting cell types like dendritic cells and macrophages, and enhances B-T cell interactions in the tumor microenvironment. Use genetically diverse mouse models to explore the role of specific immune cell populations, including B cells, T cells, dendritic cells, and macrophages, in eliciting durable anti-tumor immunity when SEMA4D is blocked in combination with immune checkpoint inhibitors. Determine if targeting the LAG3 inhibitory checkpoint can serve as a more tolerable and effective alternative to CTLA-4 blockade to overcome resistance to SEMA4D/PD-1 therapy. The research aims to uncover the mechanistic basis for how SEMA4D-targeting regimens sustain durable anti-tumor immunity and how this approach can be combined with LAG3 blockade for future clinical translation across solid tumors.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $265.8k | 3/27/25 | ||
| Not listed | $443.8k | 3/26/25 |