Project Grant R01CA299969

Award Date 5/16/25
Completion Date 4/30/30
Dollars Obligated $745K
Federal Grant Program
93.393
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
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The research aims to: 1) Determine if follicular fluid promotes LINE-1 expression in fallopian tube epithelial cells, and 2) Investigate whether LINE-1 expression contributes to genetic instability in fallopian tube epithelial cells, independently or in combination with other known pre-malignant genetic alterations, to facilitate the development of a hyperplastic and eventually neoplastic phenotype. The study will utilize patient samples, established and novel assays, as well as state-of-the-art technologies to elucidate the genomic impact of LINE-1 in fallopian tube epithelial cells and its potential role in the malignant transformation leading to HGSOC. The findings from this research are expected to inform the development of new strategies to target or prevent ovarian cancer.

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