Project Grant R01CA299654
- Federal Grant Award Summary The National Cancer Institute awarded University of California, San Diego a $699,929 Project Grant on June 20, 2025, under the Cancer Treatment Research program (CFDA 93.395) to enhance immunotherapy response in human papillomavirus negative head and neck squamous cell carcinoma (HPV-HNSCC). The project, which extends through May 31, 2030, focuses on improving dendritic cell (DC) migration to draining sentinel lymph nodes to enhance the efficacy of programmed...
- Federal Grant Award Summary The National Cancer Institute awarded a Project Grant totaling $650,597 to the University of California, San Diego, effective April 1, 2026, through March 31, 2031, under the Cancer Treatment Research program (CFDA 93.395). The research project investigates the role of B-cells in generating durable complete responses to checkpoint blockade immunotherapy in head and neck squamous cell carcinoma patients. The study addresses the observation that while response rates...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $988,224 to the University of California, San Diego under the Cancer Treatment Research program (CFDA 93.395) for the period September 1, 2025 through August 31, 2029. This project grant supports clinical research activities focused on advancing treatment strategies for head and neck cancer patients with competing health risks, particularly older populations and medically underserved groups who are ineligible for...
- Federal Grant Award Summary The University of Arkansas for Medical Sciences (UAMS) received a $1.15M Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through May 31, 2030. This Phase III COBRE (Centers of Biomedical Research Excellence) award funds the Center for Studies of Host Response to Cancer Therapy, which develops research infrastructure, support...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Emory University a $156,500 Project Grant on August 1, 2025, under the Cancer Treatment Research program (CFDA 93.395) to conduct integrated multi-omics research exploring the pathophysiology of cachexia in head and neck squamous cell carcinoma (HNSCC) patients. The two-year project, concluding July 31, 2027, will investigate the systemic biological mechanisms underlying cancer cachexia through comprehensive analysis of...
- Federal Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $186,000 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on June 23, 2025, with a completion date of May 31, 2027. The award supports pilot and feasibility studies for NN-01-195, a novel tumor-targeted Aurora-A kinase (AURKA) inhibitor developed through a drug conjugate approach. The research involves preclinical evaluation of this chimeric compound, which fuses an...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of North Carolina at Chapel Hill a Project Grant totaling $624,194 under the Cancer Biology Research program (CFDA 93.396) effective April 1, 2026 through March 31, 2031. This five-year award supports fundamental research investigating how the integrated stress response (ISR) regulates CD8+ tumor-infiltrating lymphocyte (TIL) function and immunometabolism within the tumor microenvironment (TME). The research...
- Federal Grant Award Summary The National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) awarded a $634,644 Project Grant to the University of Wisconsin-Madison on March 12, 2026, with a completion date of February 28, 2031. This research initiative focuses on developing and evaluating treatment interventions for chemoradiation-induced dysphagia (difficulty swallowing) resulting from head and neck cancer treatment. The project investigates the therapeutic potential of...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under the Cancer Research Manpower program (CFDA 93.398), awarded a $101,916 Project Grant to the University of Massachusetts Medical School (UMMS) effective December 1, 2025, through May 11, 2028. This award supports basic biomedical research investigating replication gap suppression mechanisms in chemoresistant BRCA1 and BRCA2 (BRCA) mutant hereditary breast and ovarian cancers (HBOC). The funded research aims to identify...
- Federal Project Grant Award Summary The National Cancer Institute awarded $460,548 to the University of Arkansas for Medical Sciences under the Cancer Biology Research program (CFDA 93.396) for a five-year project grant (April 1, 2026 through March 31, 2031) investigating the pathogenesis of gammaherpesvirus and Plasmodium coinfections. The research addresses the hypothesis that coinfections with Epstein-Barr virus (EBV) and the malaria parasite Plasmodium falciparum cooperate to promote Burkitt...
The University of Arkansas for Medical Sciences (UAMS) received a $628,980 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) on May 1, 2026, with a completion date of April 30, 2031. The grant supports research exploring the GSK3B-53BP1 axis in immune control of head and neck squamous cell carcinoma (HNSCC), with the objective of enhancing T cell survival and immunotherapy efficacy. The research deliverables include three primary investigative aims: (1) characterization of how GSK3B inhibits 53BP1 in DNA repair and T cell survival following radiation exposure; (2) evaluation of tumor-infiltrating lymphocyte function and immune checkpoint blockade response when the GSK3B-53BP1 axis is disrupted; and (3) assessment of therapeutic potential using 53BP1 mutant T cells in adoptive cell transfer therapy for HNSCC treatment. This research project addresses the critical clinical challenge of T cell exhaustion, which limits the effectiveness of immunotherapies in cancer patients. The funded research will generate preclinical and translational science products through laboratory investigations using a knock-in mouse model, ultimately contributing to the development of improved cancer immunotherapy approaches. By examining DNA repair mechanisms and T cell function in the context of radiation and immunotherapy combination treatments, this project supports the broader Cancer Treatment Research program objective of developing improved methods to cure cancer patients and control disease progression.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $629.0k | 4/21/26 |