Project Grant R01CA299473
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Virginia a $192,887 Project Grant under the Cancer Research Manpower program (CFDA 93.398) beginning May 8, 2026, with an ultimate completion date of April 30, 2029. This award supports biomedical research and training focused on sphingolipid-guided stratification and therapeutic opportunities in acute myeloid leukemia (AML). The project delivers research services aimed at improving AML risk...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Virginia a $404,349 Project Grant under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) for the period April 1, 2026 through March 31, 2028. The grant funds the development and validation of an innovative magnetic resonance imaging (MRI) approach to quantify focused ultrasound-mediated macromolecular delivery to brain tumors, specifically brain metastases. The research implements quantitative...
- Federal Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $186,000 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on June 23, 2025, with a completion date of May 31, 2027. The award supports pilot and feasibility studies for NN-01-195, a novel tumor-targeted Aurora-A kinase (AURKA) inhibitor developed through a drug conjugate approach. The research involves preclinical evaluation of this chimeric compound, which fuses an...
- Federal Grant Award Summary The National Cancer Institute awarded $138,846 to the University Health Network under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for a two-year Project Grant commencing August 1, 2025 and concluding July 31, 2027. The award supports the development of laboratory-generated "wild-like" mouse models designed to enhance the translational relevance of preclinical cancer and immunotherapy research. The primary deliverable involves adapting...
- Federal Grant Award Summary The National Cancer Institute awarded $584,510 under the Cancer Biology Research program (CFDA 93.396) to the University of Colorado-Denver on September 12, 2025, for development of high parameter spatial transcriptomics and proteomics technologies to study tumor microenvironments. The award, which extends through August 31, 2029, supports continued operations and advancement of the Human Immune Monitoring Shared Resource (HIMSR), a specialized service unit within the...
- Federal Grant Award Summary The University of Virginia received a $192,888 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective September 1, 2025, through August 31, 2028. This award supports a novel research initiative designed to identify causal genetic variants associated with colorectal cancer (CRC) risk and elucidate their mechanistic effects through the use of normal colon organoids. The project addresses a critical gap in...
- Federal Grant Award Summary The University of Virginia received a $2.66 million Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded September 1, 2025, through August 31, 2030. The award supports a coordinated research initiative to develop ceramide-directed therapeutics for acute myeloid leukemia (AML) treatment. The program integrates three inter-related research projects and four essential core facilities to define the biological...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $421,685 Project Grant to The Regents of the University of California, San Francisco under the Cancer Biology Research program (CFDA 93.396) for research activities spanning August 8, 2025 through July 31, 2027. This award funds a discovery-focused research initiative investigating functional immune niches within the tumor microenvironment (TME) that support effective cancer immunotherapy responses. The primary deliverable...
- Federal Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a $368,294 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period September 1, 2025 through August 31, 2028. This award supports the development of next-generation platforms for interrogating T cell receptor (TCR) specificity to identify and detect tumor antigens at the protein level. The project addresses a critical bottleneck in cancer...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $733,864 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the Beckman Research Institute of the City of Hope, effective June 1, 2026, through May 31, 2031. This five-year research initiative focuses on identifying and characterizing stimulatory immune checkpoints that regulate macrophage-mediated programmed cell removal (PRCR) in tumor immunosurveillance. Using high-throughput CRISPR-based screening...
The National Cancer Institute awarded the University of Virginia a $484,387 Project Grant on May 7, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop novel statistical methods for analyzing Enzyme-Linked Immunospot (ELISPOT) assay data. The project, which runs through April 30, 2030, addresses a critical gap in standardizing ELISPOT analysis across clinical and translational immunology studies. ELISPOT assays are widely used to quantify cytokine-secreting cells and serve as immunogenicity endpoints in early-stage therapeutic trials, yet inconsistent analytical approaches across studies limit comparisons and reproducibility. The primary deliverables include the development and validation of a statistical method that treats ELISPOT data as a continuous measure adjusted for negative and positive controls, replacing the currently fragmented dichotomous response definitions used across studies. Using existing clinical trial datasets, the research team will demonstrate the superior statistical power of the continuous approach and assess whether immunologic response patterns correlate with long-term clinical outcomes. The project will also generate innovative statistical methodologies applicable to broader research applications beyond ELISPOT analysis, supporting the Cancer Treatment Research program's objectives to advance cancer therapeutic development through improved analytical rigor and evidence generation.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $484.4k | 5/11/26 |