This Project Grant award of $662,938, provided by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), supports research at Northwestern University to investigate the role of gain-of-function mutant p53 proteins in acute myeloid leukemia (AML). The central objective is to determine how these p53 mutations promote leukemia-initiating cell self-renewal, chromatin accessibility, and 3D chromatin structure, which may contribute to therapy resistance in AML. The research employs a multidisciplinary approach including molecular, genetic, and genomic techniques such as RNA-seq, ATAC-seq, ChIP-seq, and Hi-C to elucidate the mechanisms by which mutant p53 proteins drive leukemogenesis. This 5-year project, running from December 2024 to November 2029, aims to uncover novel therapeutic targets for treating TP53-mutant AML, which is associated with poor prognosis.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $662.9k | 12/10/24 |