This federal Project Grant award, issued by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), supports research at New York University School of Medicine to investigate the molecular mechanisms underlying the adeno-to-squamous transition in non-small cell lung cancer treatment. The $703,410 award, with a project period from January 16, 2025 to December 31, 2029, aims to identify vulnerabilities in the chromatin regulators driving this adaptive transition, as well as decouple the relationship between lineage state and resistance programs to inform new therapeutic approaches. The research leverages mouse models, organoid studies, and patient-derived xenografts to systematically screen chromatin remodelers and perform CRISPR-based dropout screens to elucidate the key molecular drivers. This work seeks to address an important clinical challenge in treating lung cancer by disrupting an escape mechanism to KRAS inhibitor therapy.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $703.4k | 1/16/25 |