This Project Grant award from the National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), aims to define the signatures of epigenetic sensitization that predispose to lung cancer development in a mouse model. The $234,730 award, granted on July 9, 2024, will support a 2-year research project at Yale University to: The project seeks to reveal new markers for epigenetic risk of lung tumorigenesis and define the molecular signatures associated with prior epigenetic sensitization in lung tumors. This work leverages a unique mouse model where epigenetic changes induced in the paternal germline result in elevated lung tumor burden in offspring, providing an opportunity to study how preexisting epigenetic perturbations interact with genetic drivers to enhance lung cancer development. The findings could lead to improved strategies for predicting cancer risk and classifying tumors based on their epigenetic state.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $234.7k | 7/9/24 |