This Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, totaling $713,601, supports a research project titled "Homologous Recombination Repair Pathway Mutations and Genetic Mechanisms Shaping Anti-Tumor Immunity and Immunotherapy Efficacy". The research aims to elucidate how defects in the homologous recombination DNA repair pathway influence the efficacy of immune checkpoint blockade therapies in cancer treatment. Key objectives include characterizing the mechanisms underlying differential immunogenicity between BRCA1 and BRCA2 mutant tumors, assessing the impact of homologous recombination repair defects on immunotherapy response in human tumors, and examining mechanisms of acquired resistance in homologous recombination defective tumors that progress after immunotherapy. The project period runs from Aug 1, 2025 to Jul 31, 2030.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $713.6k | 6/19/25 |