This federal Project Grant award, provided by the National Cancer Institute (NCI) under the Cancer Treatment Research Program (CFDA 93.395), aims to investigate how certain bacteria associated with immune checkpoint inhibitor (ICI) therapies can modulate anti-tumor immunity in melanoma. The $636,222 grant, with a performance period from April 1, 2025 to March 31, 2030, will fund research conducted by the University of Pittsburgh to test whether ICI-associated bacteria can metabolize dietary tryptophan into aryl hydrocarbon receptor (AhR) ligands, which may enhance CD8+ T cell-mediated antitumor immunity and improve the efficacy of ICI therapies, both in ICI-sensitive and ICI-resistant melanoma models. The research will explore the AhR-dependent and independent mechanisms by which these bacterial metabolites modulate CD8+ T cell function to potentially inform the development of new approaches to enhance the clinical benefits of existing ICI treatments for melanoma patients.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $636.2k | 4/1/25 |