Project Grant R01CA293596

Award Date 9/1/24
Completion Date 8/31/29
Dollars Obligated $664K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30322, USA
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This $570,096 Project Grant award from the National Cancer Institute (under CFDA 93.395 - Cancer Treatment Research) supports research by Northwestern University to investigate how the epigenetic regulator EZH2 impacts RNA modifications, particularly N6-methyladenosine (m6A), in the progression of advanced prostate cancer. The project aims to precisely identify the non-canonical role of EZH2 in regulating m6A levels, as the researchers have found that dysregulation of EZH2 alters m6A, leading to...
This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) will provide $582,198 to Northwestern University from Jul 12, 2024 to Jun 30, 2029 to conduct research on the role of the EZH2 protein in regulating PARP1 function and PARP inhibitor resistance in prostate cancer. The research aims to identify how EZH2-mediated PARP1 methylation impacts DNA damage repair and transcription activity, with the goal of developing new EZH2 and PARP1...
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The National Cancer Institute (NCI) awarded a Project Grant under the Cancer Treatment Research program (CFDA 93.395) to Emory University to develop protein degraders targeting the non-enzymatic functions of the EZH2 protein in prostate cancer. The $663,713 award, which runs from September 1, 2024 to August 31, 2029, aims to create novel proteasome-targeting chimeric molecules (PROTACs) that can degrade EZH2, a key driver of castration-resistant prostate cancer progression. The research will test the efficacy of these PROTAC compounds in prostate cancer models and help dissect the catalytic and non-catalytic roles of EZH2 in different stages of the disease. Emory University has also issued a $118,551 sub-award to Northwestern University to contribute complementary expertise in this effort.

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