Project Grant R01CA293091

Award Date 9/17/24
Completion Date 8/31/29
Dollars Obligated $690K
Federal Grant Program
93.393
Assistance Type
Project Grant
Place of Performance
Boston, MA 02215, USA
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This Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) totaling $459,867 provides funding to develop and clinically validate natural language processing methods, particularly neural language models, to extract and monitor immune-related adverse events (IRAEs) from electronic health records (EHRs) for cancer patients treated with immune checkpoint inhibitors. The project aims to improve IRAE identification, severity...
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This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $689,934 to the Dana-Farber Cancer Institute (DFCI) to conduct research on the genetic factors underlying immune-related adverse events (IRAEs) associated with immune checkpoint inhibitor (ICI) cancer treatments.

The key objectives are to: 1) Perform the largest genome-wide association study (GWAS) of IRAEs across over 13,000 ICI-treated patients, to identify shared and distinct genetic signatures for different IRAE subtypes, and evaluate how germline variants impact both safety and efficacy outcomes; and 2) Investigate the cell-type-specific mechanisms, tumor microenvironment interactions, and ancestral variability of the identified germline IRAE variants using bulk and single-cell RNA sequencing data. This research aims to personalize immunotherapy by tailoring treatments to individual genetic profiles, in order to minimize IRAEs and optimize efficacy, thereby improving cancer treatment outcomes and reducing healthcare costs associated with complications.

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