Project Grant R01CA292733
Award Date
8/1/24
Completion Date
7/31/29
Dollars Obligated
$1.9M
Federal Agency
National Cancer Institute
Federal Grant Program
93.393
Assistance Type
Project Grant
Place of Performance
Seattle, WA 98195, USA
Similar Awards
This federal Project Grant award, valued at $407,321 and awarded by the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research), supports research to investigate alternative splicing and isoform expression as mediators of the genetic etiology of breast cancer. The key objectives are to: Quantify isoform expression and alternative splicing events in breast tissue using novel transcript assemblies from long-read RNA sequencing data. This will involve benchmarking statistical...
The National Cancer Institute (NCI) awarded a $455,111 Project Grant under CFDA 93.393 "Cancer Cause and Prevention Research" to the Sloan-Kettering Institute for Cancer Research in New York. The 2-year grant, awarded on September 5, 2023, will support research to "Leverage the Hidden Genome to Recover the Missing Heritability of Cancer." The project aims to 1) estimate additional heritability that can be explained by the "hidden genome" (regions of unknown...
This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $505,613 to the Fred Hutchinson Cancer Center in Seattle, WA to develop statistical and computational approaches to leverage genomic data for precision cancer prevention. The key objectives are to: (1) create deep learning models to identify tumor subtypes linked to poor outcomes and integrate external biomarker data to assess risk factors; and (2) develop statistical...
The federal Project Grant award of $489,527 from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) to Emory University focuses on understanding the functional consequences of genetic variants in the SMARCB1 gene, which is associated with a growing number of rare and difficult-to-treat cancers. The research aims to enhance the understanding of key SMARCB1 mutations and how they impact the protein's ability to bind to other members of the SWI/SNF chromatin...
This federal Project Grant award of $380,337 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to develop predictive models that relate mRNA sequence to stability and translation. The University of Washington will combine machine learning with massively parallel reporter assays to build these models, and then use innovative design algorithms to generate synthetic 5'UTR and coding sequences that result in either high protein expression across cell types or highly...
This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) to the Sloan-Kettering Institute for Cancer Research provides $1,504,098.00 in funding to identify the genetic determinants of radiation-associated breast cancer and develop a comprehensive model for estimating contralateral breast cancer (CBC) risk. The key objectives are to screen for genetic variants that confer risk for radiation-associated CBC, and to develop and validate an...
This $279,411 Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) will fund a study examining the relationship between epigenetic aging, exercise capacity, and cardiac function in breast cancer patients receiving treatment. The study will quantify DNA methylation changes in 100 breast cancer patients and 20 non-cancer controls over a 3-month period, and analyze how these epigenetic changes correlate with changes in...
This federal Project Grant award of $635,033 from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) aims to advance understanding of the genetic basis of a recently recognized cancer-prone syndrome caused by long telomere length. The research conducted by The Johns Hopkins University will seek to identify additional novel mechanisms for this long telomere syndrome, with the goal of finding high-risk groups who could benefit from early...
This federal Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $159,803 to the Regents of the University of Michigan to incorporate emerging genomic, transcriptomic, epigenomic, and proteomic technologies for the analysis of advanced, rare, and pediatric cancers. The project aims to translate these new analytical approaches into clinically actionable information through the development of reportable test results in the...
This $131,338 federal Project Grant award was provided by the National Human Genome Research Institute (CFDA 93.172 Human Genome Research) to the University of Washington. The overarching goal of this 2-year award is to identify the functional consequences of variations in nuclear architecture on transcriptional and post-transcriptional regulation, and the role of this variation in human health and disease. Specifically, the award supports three research aims: 1) developing novel deep learning...