The National Cancer Institute (NCI) awarded a $455,111 Project Grant under CFDA 93.393 "Cancer Cause and Prevention Research" to the Sloan-Kettering Institute for Cancer Research in New York. The 2-year grant, awarded on September 5, 2023, will support research to "Leverage the Hidden Genome to Recover the Missing Heritability of Cancer." The project aims to 1) estimate additional heritability that can be explained by the "hidden genome" (regions of unknown...
The National Cancer Institute (NCI) awarded a $487,393 Project Grant under the Cancer Cause and Prevention Research (CFDA 93.393) program to the Sloan-Kettering Institute for Cancer Research in New York, NY. The grant's objective is to investigate the role of key proteins like RAD52, HELQ, and POLQ in backup DNA double-strand break repair pathways for homologous recombination deficient (HRD) cancers. The research aims to define new therapeutic targets and develop functional assays to identify...
This $589,425 Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research (CFDA 93.393) federal grant program supports research to develop machine learning radiogenomic (ML-RGX) models to predict and mitigate late radiation toxicities in prostate cancer patients. The primary awardee, The Medical College of Wisconsin, Inc., will train ML-RGX models to predict radiation-induced genitourinary (GU) and gastrointestinal (GI) toxicities, and externally...
This Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) to SRI International provides $401,125 in funding to quantify the association between genetic factors and radiation sensitivity in cancer patients. The research aims to identify germline genetic variants and gene expression patterns that contribute to individual differences in radiation response. The goal is to develop a predictive screening platform to optimize radiation dosing and mitigate...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides funding to Brigham & Women's Hospital Inc. to study the role of DNA damage and stemness in the initiation of BRCA1-related breast cancer. The $527,159 award, running from January 1, 2025 to December 31, 2029, will support research to investigate how DNA damage, particularly interstrand crosslink (ICL) DNA damages, can induce a fetal mammary stem cell-like program in...
The National Cancer Institute awarded a $256,487 Project Grant under the Cancer Research Manpower (CFDA 93.398) program to the Sloan-Kettering Institute for Cancer Research in New York, NY. The grant supports a 5-year research project to develop multimodal predictive models combining real-world data from circulating tumor DNA (ctDNA) sequencing, radiomics, tumor genomics, and clinical notes to improve risk stratification and clinical management of non-small cell lung cancer (NSCLC). The research...
The National Cancer Institute (NCI) awarded a $942,442 Project Grant under the Cancer Cause and Prevention Research (CFDA 93.393) program to the Dana-Farber Cancer Institute, Inc. (DFCI) in Boston, MA. The grant, effective September 1, 2024, supports research to identify the mechanisms driving rapid evolution of cancer genomes, with a focus on understanding the processes of chromothripsis and chromoplexy. The research aims to advance the fundamental knowledge of these catastrophic mutational...
This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Cause and Prevention Research (CFDA 93.393) program, provides $645,196 in funding to the University of Washington for a 5-year research project starting on August 1, 2024. The research aims to discover and characterize new classes of non-coding genetic variations that may contribute to inherited predisposition for breast and ovarian cancer. The project will leverage advanced genomic sequencing,...
The National Cancer Institute (NCI) awarded a $187,000 Project Grant under the Cancer Cause and Prevention Research (CFDA 93.393) program to Northwestern University for the project "Lipid-Initiated Epigenetic Reprogramming of the Breast to a Neural Phenotype." This innovative research aims to explore how changes in lipid metabolism pathways and associated epigenetic modifications may contribute to the development of estrogen receptor-negative breast cancer. The study utilizes an in...
The National Cancer Institute (NCI) awarded a $450,000 Project Grant under the Cancer Biology Research (CFDA 93.396) program to The Research Foundation For The State University Of New York (Stony Brook University) to develop advanced topological data analysis (TDA) methods for extracting and interpreting fine-grained structural information from breast imaging. The project, titled "Topological Methods for Breast Tissue Quantification," aims to create a suite of TDA-driven techniques...