This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $542,663 to The University of Texas MD Anderson Cancer Center to conduct preclinical research on the efficacy of BRG1/BRM antagonists, both inhibitors and degraders, against acute myeloid leukemia (AML) with MLL rearrangement or mutant NPM1. The key objectives are to: Determine the preclinical efficacy of BRG1/BRM antagonists, and associated changes in the epigenome, transcriptome, and proteome, in patient-derived AML cells with MLL rearrangement or mutant NPM1, including those resistant to menin inhibitor treatment. Evaluate the preclinical efficacy of BRG1/BRM antagonist-based combinations, using in vitro patient-derived AML cells and in vivo patient-derived xenograft models of AML with MLL rearrangement or mutant NPM1. Determine the ability of BRG1/BRM antagonist-based combinations to overcome menin inhibitor resistance due to epigenetic, adaptive, or menin mutation mechanisms in patient-derived AML cells. The award period is from April 11, 2025 to March 31, 2030, supporting this comprehensive preclinical research program to advance novel targeted therapies for challenging AML subtypes.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $542.7k | 4/11/25 |