Project Grant R01CA291918

Award Date 4/11/25
Completion Date 3/31/30
Dollars Obligated $543K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Texas, USA
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This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $542,663 to The University of Texas MD Anderson Cancer Center to conduct preclinical research on the efficacy of BRG1/BRM antagonists, both inhibitors and degraders, against acute myeloid leukemia (AML) with MLL rearrangement or mutant NPM1. The key objectives are to:

  1. Determine the preclinical efficacy of BRG1/BRM antagonists, and associated changes in the epigenome, transcriptome, and proteome, in patient-derived AML cells with MLL rearrangement or mutant NPM1, including those resistant to menin inhibitor treatment.

  2. Evaluate the preclinical efficacy of BRG1/BRM antagonist-based combinations, using in vitro patient-derived AML cells and in vivo patient-derived xenograft models of AML with MLL rearrangement or mutant NPM1.

  3. Determine the ability of BRG1/BRM antagonist-based combinations to overcome menin inhibitor resistance due to epigenetic, adaptive, or menin mutation mechanisms in patient-derived AML cells.

The award period is from April 11, 2025 to March 31, 2030, supporting this comprehensive preclinical research program to advance novel targeted therapies for challenging AML subtypes.

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