Project Grant R01CA290796

Award Date 1/3/25
Completion Date 12/31/29
Dollars Obligated $436K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Baltimore, MD 21201, USA
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This $465,020 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research by the University of Maryland, Baltimore to investigate how chemotherapy used to treat ovarian cancer can inadvertently stimulate tumor-associated enzymes that promote metastasis. The goal is to determine the specific mechanisms by which chemotherapy activates these enzymes, in order to develop strategies to neutralize the pro-metastatic effects. The 5-year research...
This $473,100 federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research by the University of Maryland, Baltimore to investigate the role of neddylation in the repair of topoisomerase I inhibitor-induced replication damage in colorectal cancer. The research aims to assess the combination of the topoisomerase I inhibitor irinotecan and the NEDD8-activating enzyme inhibitor pevonedistat in colorectal cancer preclinical models,...
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