The Regents of the University of California, San Francisco (UCSF) received a $676,006 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394). This 5-year grant, awarded on July 28, 2025, supports the development and testing of innovative molecular imaging strategies to rapidly identify mechanisms of immunotherapy resistance in cancer patients. The research aims to utilize PET imaging, implantable fluorescent sensors, and high-parameter tissue analysis to measure key biomarkers of response and resistance, such as granzyme B levels and neutrophil infiltration, shortly after initiating immunotherapy treatment. By enabling early detection of resistance mechanisms, this project seeks to facilitate precision medicine approaches that can improve outcomes for cancer patients receiving immunotherapies.
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