Project Grant R01CA289486
- This federal Project Grant award of $162,519 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research to refine and pilot test a psychological intervention aimed at improving the emotional well-being of family caregivers of children with medical complexity (CMC). The principal investigator, Dr. Yu, will collaborate with CMC caregivers and clinicians to...
- This $708,091 federal Project Grant award from the National Cancer Institute (CFDA 93.393 Cancer Cause and Prevention Research) supports the "Algorithm-Enabled Patients Activated in Cancer Care Through Teams (A-PACT)" project. The goal of this 5-year project is to test the effectiveness of the A-PACT intervention, which uses machine learning algorithms to automatically identify high-risk cancer patients who need goals of care conversations. This allows for scalable delivery of...
- The Project Grant award of $403,822, awarded by the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research), will fund a pilot study to develop and test the "DESCANSO" cognitive behavioral therapy (CBT) intervention to treat the symptom cluster of depression, insomnia, and fatigue in Spanish-speaking Latino cancer patients. The study aims to culturally adapt the DESCANSO intervention, which combines CBT strategies to address insomnia, depression, and...
- This Project Grant award of $2,746,080, provided by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), supports research on the effects of remotely-delivered cognitive behavioral stress management (R-CBSM) on cancer-accelerated aging in older, distressed breast cancer survivors. The project will enroll 192 breast cancer survivors within 3-12 months of completing initial treatment, some of whom received chemotherapy. Participants will undergo...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $157,000.00 to support a pilot study evaluating the acceptability and feasibility of a 6-week nature meditation intervention for bereaved friend and family caregivers of cancer patients who died in hospice care. The study, conducted by the collaborative research partnership of Henry Ford Health and Michigan State University Health Sciences, aims to develop 6 nature-based healing meditation...
- This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $166,000 to the University of Southern California to examine how implicit attitudes towards physical activity can mediate the effects of different interventions on physical activity behavior among adults at elevated cancer risk due to inactivity and overweight/obesity. The key products or services being delivered under this grant include: 1) Assessing implicit attitudes...
- The National Cancer Institute (NCI), under the Cancer Cause and Prevention Research federal grant program (CFDA 93.393), awarded a $427,085 Project Grant to New York University (NYU) to conduct research on the cross-talk between social determinants of health and the mTOR pathway, and its impact on post-treatment fatigue in prostate cancer patients. The research aims to understand how factors such as dietary adversity, socioeconomic status, and genetic factors influence biological pathways...
- This $656,046 Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) supports a randomized clinical trial of a novel behavioral intervention called EASE to address fear of progression and cancer-related trauma symptoms in adults with advanced cancer. The intervention, adapted from written exposure therapy, aims to help this population reduce their fear of the future and associated negative outcomes. The 5-year study is...
- The National Center for Complementary and Integrative Health (NCCIH), part of the Department of Health and Human Services, awarded a $170,604 Project Grant under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The grant funds the development, refinement, and pilot testing of the "Resilient Together-ALS (RT-ALS)" intervention, a mind-body and meaning-based...
- This Project Grant award of $750,079 from the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) aims to develop and pilot test a combined "SMART-QTC" intervention for Asian American patients with co-occurring major depressive disorder and distressing somatic symptoms. The grantee, The General Hospital Corporation (doing business as Massachusetts General Hospital), will...
ACCEPTANCE AND COMMITMENT THERAPY FOR PATIENT FATIGUE INTERFERENCE AND CAREGIVER BURDEN IN ADVANCED GASTROINTESTINAL CANCER - PROJECT SUMMARY/ABSTRACT FATIGUE INTERFERENCE WITH ACTIVITIES, MOOD, AND COGNITION IS ONE OF THE MOST PREVALENT AND DISTRESSING CONCERNS OF ADVANCED GASTROINTESTINAL CANCER PATIENTS. AS FATIGUE INTERFERES WITH PATIENT FUNCTIONING, FAMILY CAREGIVERS OFTEN REPORT FEELING BURDENED BY INCREASING RESPONSIBILITIES. EVIDENCE-BASED INTERVENTIONS ADDRESSING CANCER PATIENT FATIGUE INTERFERENCE AND CAREGIVER BURDEN ARE LACKING. IN PILOT STUDIES, ACCEPTANCE AND COMMITMENT THERAPY (ACT) HAS SHOWN POTENTIAL FOR REDUCING SYMPTOM-RELATED SUFFERING IN CANCER PATIENTS. WE RECENTLY CONDUCTED A PILOT STUDY TESTING A NOVEL, DYADIC ACT INTERVENTION FOR PATIENTS AND FAMILY CAREGIVERS COPING WITH ADVANCED GASTROINTESTINAL CANCER. THE INTERVENTION COMBINES ACCEPTANCE AND MINDFULNESS EXERCISES (E.G., MEDITATIONS, PERFORMING ACTIVITIES WITH GREATER AWARENESS) WITH IDENTIFICATION OF PERSONAL VALUES AND ENGAGEMENT IN ACTIVITIES CONSISTENT WITH THESE VALUES. THIS TELEPHONE-BASED INTERVENTION SHOWED STRONG EVIDENCE OF FEASIBILITY, ACCEPTABILITY, AND PROMISE FOR REDUCING PATIENT FATIGUE INTERFERENCE WITH FUNCTIONING AND CAREGIVER BURDEN. THE PROPOSED PHASE II TRIAL SEEKS TO MORE DEFINITIVELY EXAMINE THE EFFICACY OF OUR TELEPHONE- BASED ACT INTERVENTION FOR ADVANCED GASTROINTESTINAL CANCER PATIENTS WITH MODERATE TO SEVERE FATIGUE INTERFERENCE AND THEIR FAMILY CAREGIVERS WITH SIGNIFICANT CAREGIVING BURDEN. IN THIS TRIAL, 244 PATIENT-CAREGIVER DYADS WILL BE RANDOMLY ASSIGNED IN EQUAL NUMBERS TO EITHER THE ACT INTERVENTION OR AN EDUCATION/SUPPORT CONTROL CONDITION. DYADS IN BOTH CONDITIONS WILL ATTEND SIX WEEKLY 50-MINUTE TELEPHONE SESSIONS. THE PRIMARY AIM OF THIS STUDY IS TO TEST THE EFFECT OF TELEPHONE-DELIVERED ACT ON PATIENT FATIGUE INTERFERENCE AND CAREGIVER BURDEN. SECONDARY OUTCOMES INCLUDE PATIENT SLEEP INTERFERENCE AND PATIENT AND CAREGIVER ENGAGEMENT IN DAILY ACTIVITIES AND QUALITY OF LIFE. OUTCOMES WILL BE ASSESSED AT BASELINE, 2 WEEKS POST-INTERVENTION, AND 3 MONTHS POST-INTERVENTION. THIS TRIAL WILL ALSO EXAMINE WHETHER INCREASES IN PSYCHOLOGICAL FLEXIBILITY, DEFINED AS FULL AWARENESS OF THE PRESENT MOMENT WHILE PERSISTING IN ACTION ALIGNED WITH PERSONAL VALUES, ACCOUNT FOR THE BENEFICIAL EFFECT OF ACT ON PRIMARY OUTCOMES. DEMONSTRATING ACT'S EFFICACY WILL SUPPORT ITS ADOPTION IN CANCER CARE. THIS TRIAL WILL ALSO LAY THE GROUNDWORK FOR FURTHER APPLICATION AND TESTING OF ACT WITH A WIDE RANGE OF PATIENTS AND CAREGIVERS COPING WITH SERIOUS ILLNESSES AND FUNCTIONAL OUTCOMES.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $554.1k | 5/7/25 | ||
| Not listed | $645.9k | 4/19/24 | ||
| Not listed | $645.9k | 4/19/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
10169S | Northwestern University | Project Grant R01CA289486 | $137.4k | 8/13/24 | |
10159S | The Univeristy Of Texas M.d. Anderson Cancer Center | Project Grant R01CA289486 | $123.4k | 7/24/24 |