This federal Project Grant award, totaling $552,763, was provided by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant funds research aimed at assessing the therapeutic potential of newly developed KAT6 inhibitors (KAT6is) as monotherapy and in combination with targeted therapy drugs for the treatment of high-grade serous ovarian cancer (HGSOC) and triple-negative breast cancer (TNBC). The research focuses on characterizing the epigenetic changes induced by KAT6i treatment, defining the mechanism of action of KAT6i in KAT6A-dependent cancers, and evaluating the therapeutic potential of KAT6i in preclinical models of these cancer types. The goal of this work is to provide a strong rationale for KAT6A as a novel drug target for cancer treatment. The award period runs from January 1, 2025 through December 31, 2029.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $552.8k | 12/31/24 |