Project Grant R00CA263149

Award Date 7/2/24
Completion Date 6/30/27
Dollars Obligated $249K
Federal Grant Program
93.396
Assistance Type
Project Grant
Place of Performance
Cambridge, MA 02142, USA
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The key products and services to be delivered through this funding include:

  1. Defining how somatic mutations dysregulate transcriptional patterns and dictate glioma cell lineage structure (Aim 1).
  2. Measuring single-cell DNA methylation and transcriptional profiles longitudinally in patient samples to test the hypothesis that dysregulated epigenetic patterns contribute to glioma progression, and providing epigenetic markers to track progression clinically (Aim 2).
  3. Developing a tool to infer glioma cell state composition, progression, and likely treatment response from routine bulk DNA methylation assays, to improve clinical diagnosis (Aim 3).

This research aims to advance the understanding of intrinsic determinants of glioma tumor progression and treatment response, with the goal of enabling novel therapies and optimal timing of interventions.

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