The National Cancer Institute (NCI) awarded a Project Grant (CFDA 93.395 - Cancer Treatment Research) to Mayo Clinic in Rochester, MN. The $633,705 grant, awarded on December 11, 2024, aims to investigate the mechanisms underlying PARP inhibitor (PARPi) resistance in prostate cancer and identify potential strategies to overcome this resistance. The research project has three specific aims: 1) Investigate the role of the NSD3S histone methyltransferase isoform in regulating DNA replication dynamics and its contribution to PARPi resistance, 2) Understand the mechanisms responsible for NSD3S upregulation in PARPi-resistant prostate cancer cell lines, and 3) Explore new approaches to overcome PARPi resistance in prostate cancer using in vitro and in vivo models. Successful completion of this study is expected to provide insights into the mechanisms of PARPi resistance and replication fork dynamics driven by NSD3S, with potential implications for developing precision medicine approaches in prostate cancer treatment.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $633.7k | 12/11/24 |