Project Grant R01CA288753

Award Date 12/11/24
Completion Date 11/30/29
Dollars Obligated $634K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Rochester, MN 55905, USA
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The research project has three specific aims: 1) Investigate the role of the NSD3S histone methyltransferase isoform in regulating DNA replication dynamics and its contribution to PARPi resistance, 2) Understand the mechanisms responsible for NSD3S upregulation in PARPi-resistant prostate cancer cell lines, and 3) Explore new approaches to overcome PARPi resistance in prostate cancer using in vitro and in vivo models. Successful completion of this study is expected to provide insights into the mechanisms of PARPi resistance and replication fork dynamics driven by NSD3S, with potential implications for developing precision medicine approaches in prostate cancer treatment.

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