Project Grant R01CA288403
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) is providing $827,942.00 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to investigate a novel inhibitory receptor that regulates the persistence and function of chimeric antigen receptor (CAR)-engineered T cell therapy for lymphoma. The key objectives are to: 1) examine the causal role of this inhibitory receptor axis in impairing the therapeutic...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $399,958 to Mabswitch Inc., a minority-owned small business, to assess the feasibility of regulating the activation, effector functions, and cytokine release of chimeric antigen receptor (CAR) T-cell therapies. The project aims to develop a "switchable affinity CAR" (SAEFCAR) that can be controlled by an exogenously administered ligand, potentially mitigating the toxicity...
- This $400,000 Project Grant was awarded on August 4, 2025 by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395). The grant supports research conducted by Lifengine Animal Health Laboratories Incorporated to develop chimeric antigen receptor (CAR)-T cell therapies that can overcome functional exhaustion. Specifically, the project aims to engineer CAR-T cells to overexpress the C-MYB transcription factor, which has been shown in mice to enhance anti-tumor...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $400,000 to Kure Ai Inc. to develop a novel CAR-T cell therapy product targeting the MR1 antigen expressed on the surface of various tumor cells, including acute myeloid leukemia (AML) and glioblastoma. The key objectives are to: 1) assess MR1 expression in primary patient AML and glioblastoma samples, 2) perform mouse efficacy studies using AML and glioblastoma models, and 3)...
- This $399,669 federal Project Grant awarded by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to establish the feasibility of commercializing a personalized and multi-targeted adoptive T cell therapy (ATCT) for glioblastoma (GBM), the most common and deadly primary brain tumor. The key products or services to be delivered under this grant include: Evaluating the ability of the applicant's Prussian blue nanoparticle-based photothermal therapy (PBNP-PTT) platform to...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) is focused on enhancing cancer therapeutics through the development of a 3-in-1 Chimeric Antigen Receptor (CAR) T cell approach. The $398,997 award, effective July 1, 2025 through June 30, 2026, supports research by Immunogenik, Inc. to target tumor-associated myeloid cells (TAMCs), including tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), which play a...
- This federal Project Grant award of $470,759 from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) supports research to develop a novel CAR T-cell therapy for patients with hepatocellular carcinoma. The goal is to prevent CAR T-cell exhaustion, a key barrier to effective solid tumor treatment, by overexpressing the JMJD6 transcription factor using a precise, RNA-level control system called the "PA-Regulator" platform. The research, conducted...
- This $1,340,987 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to revolutionize chimeric antigen receptor (CAR) T-cell therapy by developing a novel "CAR-Enhancer" platform to improve the effector function and persistence of CAR T-cells. The project's key objectives are to: 1) Optimize dosing and timing for CAR-Enhancer administration in a Phase I clinical trial, 2) Establish a scalable manufacturing process, and 3) Assess the...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) is supporting a Phase 2 multi-center clinical trial of a novel CD5 CAR T-cell therapy (MB-105) developed by March Biosciences Inc. for the treatment of relapsed/refractory T-cell lymphoma (R/R TCL). The $1,124,607 award, with a performance period of Jul 1, 2025 to Jun 30, 2027, aims to validate the safety and efficacy of this innovative cellular therapy that is engineered to selectively target...
- The National Cancer Institute (NCI) awarded a $402,600 Project Grant under the Cancer Treatment Research program (CFDA 93.395) to the Sloan-Kettering Institute for Cancer Research to develop novel chimeric antigen receptor (CAR) T-cell therapies targeting the U5 small nuclear ribonucleoprotein (U5 snRNP) complex for the treatment of acute myeloid leukemia (AML). The primary goals of this 5-year project are to develop these CAR T-cell therapies and investigate the mechanism by which U5 snRNP is...
DECOUPLING ACUTE TOXICITIES AND ANTITUMOR EFFICACY IN ADOPTIVE CELL THERAPY - PROJECT SUMMARY ADOPTIVE CELL THERAPY (ACT) WITH CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS HAS DEMONSTRATED IMPRESSIVE RESPONSE RATES IN B CELL MALIGNANCIES, BUT ACT HAS NOT MEDIATED SUSTAINED RESPONSES IN SOLID TUMORS. CD19 CAR T CELL THERAPY HAS REACHED UP TO 80% RESPONSE RATE IN THE CLINIC; HOWEVER, THE MAIN SIDE EFFECTS ARE CYTOKINE RELEASE SYNDROME (CRS) AND IMMUNE EFFECTOR CELL-ASSOCIATED NEUROTOXICITY SYNDROME (ICANS), WHICH OCCUR IN 37-83% AND ABOUT 25-35% OF PATIENTS, RESPECTIVELY. FURTHERMORE, ONE OF THE MAJOR OBSTACLES IN ACT IS THE HETEROGENEITY OF TARGETED ANTIGENS AND RELAPSE DUE TO ANTIGEN ESCAPE. RECENTLY, WE SCREENED A COHORT OF 16 FDA-APPROVED ANTI-INFLAMMATORY DRUGS AND IDENTIFIED CLOFAZIMINE (CLF) AS THE TOP CANDIDATE FOR ITS DESIRED BIFUNCTIONAL EFFECT FOR ANTI-CRS/ICANS AND ANTI-ANTIGEN ESCAPE ROLES. AIM 1 WILL DETERMINE THE ROLE OF CLF IN REDUCING MACROPHAGE-DERIVED ROS TO CURTAIL CRS/ICANS. AIM 2 WILL DETERMINE THE ROLE OF CLF IN DRIVING DSRNA/DSDNA SIGNALS IN MACROPHAGES FOR THE ERADICATION OF TUMORS. WE EXPECT THIS STUDY TO DEMONSTRATE THE ABILITY OF CLF IN POTENTIATING THE ANTI-ANTIGEN ESCAPE CAPACITY IN ACT, CURBING INTRACTABLE CRS, AND MAY ALSO FILL A DESPERATE CLINICAL NEED TO IMPROVE THE DISMAL PATIENT SURVIVAL WITH ICANS. THIS STRATEGY OF REPURPOSING THE CLINICALLY APPROVED CLF MAY HOLD GREAT PROMISE TO OVERCOME A CRITICAL OBSTACLE IN REALIZING THE FULL POTENTIAL OF ACT WITH CAR-T CELLS. THIS TRANSLATIONALLY RELEVANT WORK COULD THEN LAY THE FOUNDATION FOR FUTURE CLINICAL TRIALS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $59.4k | 5/26/25 | ||
| Not listed | $534.4k | 4/18/25 | ||
| Not listed | $534.4k | 4/18/25 | ||
| Not listed | $600.3k | 4/18/24 | ||
| Not listed | $600.3k | 4/18/24 |