Project Grant R01CA283394

Award Date 9/1/24
Completion Date 8/31/29
Dollars Obligated $599K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
West Lafayette, IN 47907, USA
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The key products and services to be delivered through this grant include: 1) using multi-scale modeling to define the parameter space for implant design to achieve uniform distribution of hyaluronidase within PDAC tumors, 2) using medical imaging to characterize the effects of stromal targeting agents on tumor blood flow and drug accumulation, and 3) evaluating the immunomodulatory effects and treatment efficacy of stromal targeting therapies. The goal is to establish a novel approach for targeting PDAC tumor desmoplasia, improving mass transport into tumors, and enhancing immune cell infiltration. The award recipient is Purdue University, a prominent public research institution with extensive experience executing federal grants and contracts.

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