Project Grant R01CA279596

Award Date 5/1/23
Completion Date 4/30/28
Dollars Obligated $537K
Federal Grant Program
93.394
Assistance Type
Project Grant
Place of Performance
Missouri, USA
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The Washington University will develop pre-treatment and recurrence biomarkers for locally advanced cervical cancer by analyzing variance in human papillomavirus genomic structures among patient tumors. Researchers will extract HPV genomic features from matched DNA and RNA sequencing data to test their prognostic value using samples from a cervical tumor bank. They will also examine whether treatment-induced tumor evolution can identify resistant HPV genomic structures as on-treatment biomarkers using targeted sequencing. Lastly, the team will evaluate circulating tumor DNA to develop HPV genomic structure tests for early diagnosis and post-treatment recurrence detection in combination with single nucleotide variants. The goal is to create optimized pre-treatment and recurrence biomarkers applicable in clinical settings to personalize alternative treatment regimens.

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